Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas [PDF]
, 2022 Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale rearrangements. Using whole genome short-read sequencing of 383 cases, for which 214 had matched whole transcriptomes, we observed structural variations (SV) with a
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core +11 more sources
Comprehensive profiling of extrachromosomal circular DNAs in colorectal cancer progression [PDF]
Scientific ReportsColorectal cancer (CRC) development involves a series of molecular events that drive the progression from normal colorectal epithelium to adenoma and eventually to invasive carcinoma.
Lu Lu +10 more
doaj +2 more sources
ecDNA party bus: Bringing the enhancer to you [PDF]
Molecular Cell, 2021 Recent work from Zhu et al. (2021) reveals that extrachromosomal DNA circles harboring enhancers can serve as mobile regulatory elements that interact with chromosomal oncogenes, stimulating high-level gene activity and contributing to tumor heterogeneity and cancer progression.
Karen Adelman, Benjamín Martín
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Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors [PDF]
bioRxiv, 2023 Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients.
Miin S. Lin +6 more
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Extracellular DNA Correlates with Intestinal Inflammation in Chemically Induced Colitis in Mice
Cells, 2021 Circulating extracellular DNA (ecDNA) is known to worsen the outcome of many diseases. ecDNA released from neutrophils during infection or inflammation is present in the form of neutrophil extracellular traps (NETs).
Martin Maronek +13 more
doaj +1 more source
Scientific Reports, 2022 Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequal segregation, and is associated with poor ...
Tao Wu +7 more
doaj +1 more source
BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance
SUMMARYExtrachromosomal circular DNA (ecDNA) are commonly produced within the nucleus to drive genome dynamics and heterogeneity, enabling cancer cell evolution and adaptation. However, the mechanisms underlying ecDNA biogenesis remain poorly understood.
Oliver W. Chung +11 more
openalex +3 more sources
Dynamics of Plasma and Urinary Extracellular DNA in Acute Kidney Injury [PDF]
, 2022 Early and reliable markers of acute kidney injury (AKI) are essential. One such candidate marker of tissue damage is extracellular DNA (ecDNA). The aim of our present study is to describe the unknown dynamics of ecDNA in an animal model of AKI.
Babickova, Janka +6 more
core +1 more source
Extracellular DNA concentrations in various aetiologies of acute kidney injury
Scientific Reports, 2022 Extracellular DNA (ecDNA) in plasma is a non-specific biomarker of tissue damage. Urinary ecDNA, especially of mitochondrial origin, is a potential non-invasive biomarker of kidney damage.
Alexandra Gaál Kovalčíková +10 more
doaj +1 more source
Dynamics of Urinary Extracellular DNA in Urosepsis
Biomolecules, 2023 Extracellular DNA (ecDNA) is a promising candidate marker for the early diagnosis and monitoring of urinary tract infections (UTIs). The aim of our study is to describe the dynamics of ecDNA in the plasma and urine of patients with urosepsis as well as ...
Michaela Mihaľová +6 more
doaj +1 more source