Results 41 to 50 of about 2,326 (226)

Low level of plasma DNase is associated with worse clinical outcome in testicular germ cell tumor patients and exogeneous DNase I improves (Leverages) cisplatin treatment efficacy. [PDF]

PLoS ONE
BackgroundGerm cell tumor (GCT) patients with unfavourable response to first-line therapy still lack reliable diagnostic and effective treatment Detailed correlation of total extracellular DNA (ecDNA), other DNA species and endogenous DNase levels in GCT
Michal Mego, Barbora Vikova, Katarina Kalavska, Michal Pastorek, Zuzana Cierna, Zuzana Sestakova, Miroslav Chovanec, Natalia Udvorkova, Lucia Kucerova, Peter Celec   +9 more
doaj   +2 more sources

ecDNA Inheritance Supports Tumor Heterogeneity and Evolution [PDF]

Cancer Discovery, 2022
Abstract Segregation of extrachromosomal DNA (ecDNA) is random and leads to extensive copy-number heterogeneity.

openalex   +2 more sources

Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers. [PDF]

Cancer Discov
Extrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance through its asymmetric mitotic segregation.
Montuori G, Tu F, Qin D, Schmargon R, Rodriguez-Fos E, Helmsauer K, Hui H, Mandal S, Purshouse K, Fankhänel L, Bosco B, Spanjaard B, Seyboldt H, Grunewald L, Schmitt MJ, Gürgen D, Buck V, Rosenfeldt MT, Dubois FPB, Schallenberg S, Lehmann A, Theißen J, Taschner-Mandl S, Koch A, Hundsdoerfer P, Künkele A, Eggert A, Fischer M, Gargiulo G, Krieger TG, Chavez L, Coscia F, Werner B, Huang W, Henssen AG, Dörr JR.   +35 more
europepmc   +3 more sources

Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity [PDF]

Nature Communications
Oncogene amplification is a key driver of cancer pathogenesis. Both breakage fusion bridge (BFB) cycles and extrachromosomal DNA (ecDNA) can lead to high oncogene copy numbers, but the impact of BFB amplifications on intratumoral heterogeneity, treatment
Siavash Raeisi Dehkordi, Ivy Tsz-Lo Wong, Jing Ni, Jens Luebeck, Kaiyuan Zhu, Gino Prasad, Lena Krockenberger, Guanghui Xu, Biswanath Chowdhury, Utkrisht Rajkumar, Ann Caplin, Daniel Muliaditan, Aditi Gnanasekar, Ceyda Coruh, Qiushi Jin, Kristen Turner, Shu Xian Teo, Andy Wing Chun Pang, Ludmil B. Alexandrov, Christelle En Lin Chua, Frank B. Furnari, John Maciejowski, Thomas G. Paulson, Julie A. Law, Howard Y. Chang, Feng Yue, Ramanuj DasGupta, Jean Zhao, Paul S. Mischel, Vineet Bafna   +29 more
doaj   +2 more sources

WRN Nuclease‐Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles

Advancement of science
Current research on tumor fibrosis has focused on cancer‐associated fibroblasts, which may exert dual functions of tumor promotion and inhibition. Little attention has been paid to whether tumor cells themselves can undergo fibrotic transformation and ...
Yinan Li, Xiu Huang, Yingying Li, Q. Q. Qiao, Caihong Chen, Yang Chen, Weilong Zhong, Huijuan Liu, Tao Sun   +8 more
openalex   +2 more sources

Generation of orthotopic intracranial glioblastoma patient-derived xenograft models: insights into extrachromosomal DNA-driven MYC(N) and PDGFRA oncogene amplification and preliminary therapeutic evaluation [PDF]

Neoplasia: An International Journal for Oncology Research
Background: This study aimed to establish orthotopic intracranial patient-derived xenograft (PDX) models to investigate molecular and pathological features and to evaluate potential preclinical therapeutic approaches in glioblastoma (GBM). Methods: Fresh
Thi-Anh-Thuy Tran, Sinae An, Junghyun Lim, Young-Hee Kim, Ahyeon Shim, Taewoo Han, Hawsan Kim, Sue-Jee Park, Yeong Jin Kim, Kyung-Sub Moon, In-Young Kim, Shin Jung, Chul Won Lee, Kyung-Hwa Lee, Ae Kyung Park, Tae-Young Jung   +15 more
doaj   +2 more sources

ecDNA hubs drive cooperative intermolecular oncogene expression [PDF]

Nature, 2021
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation1. Gene induction typically involves cis-regulatory elements that contact and activate genes on the same chromosome2,3.
King L. Hung, Kathryn E. Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T. Lange, Rocío Chamorro González, Natasha E. Weiser, Celine Chen, Maria E. Valieva, Ivy Tsz-Lo Wong, Sihan Wu, Siavash R. Dehkordi, Connor V. Duffy, Katerina Kraft, Jun Tang, Julia A. Belk, John C. Rose, M. Ryan Corces, Jeffrey M. Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, Anindya Bagchi, Ansuman T. Satpathy, Robert Tjian, Stefan Mundlos, Vineet Bafna, Anton G. Henssen, Paul S. Mischel, Zhe Liu, Howard Y. Chang   +33 more
openaire   +6 more sources

PATH-31. ECDNA PROMOTES TUMORIGENICITY AND INTRATUMORAL HETEROGENEITY IN MEDULLOBLASTOMA [PDF]

Neuro-Oncology, 2022
Abstract Extrachromosomal circular DNA (ecDNA) is an important driver of aggressive cancers, including medulloblastoma (MB), the most common pediatric brain tumor. To assess the clinical importance of ecDNA in MB, we applied computational methods to detect ecDNA in the genomes of a cohort of 468 MB patients and 31 MB model systems. Among
Owen Chapman, Sunita Sridhar, Shanqing Wang, Jill P. Mesirov, Lukas Chávez   +4 more
openalex   +2 more sources

Population dynamics of multiple ecDNA types [PDF]

38 pages, 6 main figures, 6 supplementary ...
Elisa Scanu, Benjamin Werner, Weini Huang   +2 more
openalex   +3 more sources

Resolving spatial subclonal genomic heterogeneity of loss of heterozygosity and extrachromosomal DNA in gliomas [PDF]

Nature Communications
Mapping the spatial organization of DNA-level somatic copy number changes in tumors can provide insight to understanding higher-level molecular and cellular processes that drive pathogenesis. We describe an integrated framework of spatial transcriptomics,
Michelle G. Webb, Frances Chow, Carmel G. McCullough, Bohan Zhang, John J. Y. Lee, Rania Bassiouni, Norman E. Garrett, Kyle Hurth, John D. Carpten, Gabriel Zada, David W. Craig   +10 more
doaj   +2 more sources