Results 61 to 70 of about 2,028 (216)

Sequence-independent identification of active LTR retrotransposons in Arabidopsis [PDF]

, 2018
Detection of retrotransposons capable of contemporary transposition is hampered by the replicative nature of their movement and is usually limited to fortuitous observations of new integration events causing visible phenotypes.
Catoni, M, Griffiths, J, Iwaski, M, Paszkowski, J   +3 more
core   +1 more source

BRD4 as a potential target for human papillomaviruses associated cancer

Journal of Medical Virology, Volume 95, Issue 12, December 2023., 2023
Abstract Around 99% of cervical cancer and 5%–10% of human cancer are associated with human papillomaviruses (HPV). Notably, the life‐cycle of HPV begins by low‐level infection of the basal cells of the stratified epithelium, where the viral genomes are replicated and passed on to the daughter proliferating basal cells.
Abdul Qawee Rani, Srinivasa Reddy Bonam, Jia Zhou, Jenny Li, Haitao Hu, Xuefeng Liu   +5 more
wiley   +1 more source

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
core   +1 more source

Specific suppression of long terminal repeat retrotransposon mobilization in plants [PDF]

, 2022
The tissue culture passage necessary for the generation of transgenic plants induces genome instability. This instability predominantly involves the uncontrolled mobilization of LTR retrotransposons (LTR-TEs), which are the most abundant class of mobile ...
Adulyanukosol, Natthawut, Brestovitsky, Anna, Catoni, Marco, Cho, Jungnam, Iwasaki, Mayumi, Paszkowski, Jerzy   +5 more
core   +2 more sources

Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte‐derived macrophages

Clinical and Translational Science, Volume 16, Issue 12, Page 2765-2778, December 2023., 2023
Abstract Neutrophil elastase (NE), a major inflammatory mediator in chronic obstructive pulmonary disease (COPD) airways, impairs macrophage function, contributing to persistence of airway inflammation. We hypothesized that NE activates a novel mechanism of macrophage‐induced inflammation: release of macrophage extracellular traps (METs).
Shuo Zheng, Apparao B. Kummarapurugu, Gamze B. Bulut, Aamer Syed, Le Kang, Judith A. Voynow   +5 more
wiley   +1 more source

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

Epigenetics & Chromatin, 2021
Background Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studies, the high-throughput short-read
Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li, Chong Tang   +13 more
doaj   +1 more source

The induction of Maspin expression by a glucosamine-derivative has an antiproliferative activity in prostate cancer cell lines [PDF]

, 2019
Mammary serine protease inhibitor or Maspin has been characterized as a class II tumor suppressor gene in several cancer types, among them prostate cancer (CaP).
Cocchiola, Rossana, de Santi, Maria Margherita, Eufemi, Margherita, Guazzo, Raffaella, Lopreiato, Mariangela, Scandurra, Roberto, Scotto d'Abusco, Anna   +6 more
core   +2 more sources

Mapping extrachromosomal DNA amplifications during cancer progression. [PDF]

Nat Genet
To understand the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression, we detected and classified focal amplifications in 8,060 newly diagnosed primary cancers, untreated metastases and heavily pretreated tumors.
Kim H, Kim S, Wade T, Yeo E, Lipsa A, Golebiewska A, Johnson KC, An S, Ko J, Nam Y, Lee HY, Kang S, Chung H, Niclou SP, Moon HE, Paek SH, Bafna V, Luebeck J, Verhaak RGW.   +18 more
europepmc   +3 more sources

Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers

Cancer Cell International, 2022
Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated extrachromosomal circular DNA has been proposed to endanger human health and speed up the progression of ...
Mohsen Karami Fath, Nastaran Karimfar, Andarz Fazlollahpour Naghibi, Shahriyar Shafa, Melika Ghasemi Shiran, Mehran Ataei, Hossein Dehghanzadeh, Mohsen Nabi Afjadi, Tahereh Ghadiri, Zahra Payandeh, Vahideh Tarhriz   +10 more
doaj   +1 more source

Detection of viable Mycobacterium ulcerans in clinical samples by a novel combined 16S rRNA reverse transcriptase/IS2404 real-time qPCR assay. [PDF]

, 2012
Detection of Viable Mycobacterium ulcerans in Clinical Samples by a Novel Combined 16S rRNA Reverse Transcriptase/IS2404 Real-Time qPCR ...
Adjei, O, Amoako, YA, Awua-Boateng, NY, Battke, F, Beissner, M, Bretzel, G, Herbinger, KH, Huber, KL, Jansson, M, Löscher, T, Phillips, RO, Sarfo, FS, Symank, D   +12 more
core   +2 more sources