Results 61 to 70 of about 2,326 (226)

The evolutionary dynamics of extrachromosomal DNA in human cancers [PDF]

, 2022
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of nonchromosomal oncogene inheritance-random identity by descent-is poorly understood.
Bafna, V, Bernkopf, M, Chang, HY, Chen, CY, Erb, ML, Henssen, AG, Huang, W, Hung, KL, Lange, JT, Liu, Z, Mischel, PS, Pichugin, Y, Rajkumar, U, Rose, JC, Shi, Q, Swanton, C, Tang, J, Taschner-Mandl, S, Werner, B, Wu, S, Xie, L, Yost, KE   +21 more
core   +6 more sources

Small ring has big potential: insights into extrachromosomal DNA in cancer

Cancer Cell International, 2021
Recent technical advances have led to the discovery of novel functions of extrachromosomal DNA (ecDNA) in multiple cancer types. Studies have revealed that cancer-associated ecDNA shows a unique circular shape and contains oncogenes that are more ...
Yihao Wang, Rui Huang, Guopei Zheng, Jianfeng Shen   +3 more
doaj   +1 more source

Dynamics of Urinary Extracellular DNA in Urosepsis

Biomolecules, 2023
Extracellular DNA (ecDNA) is a promising candidate marker for the early diagnosis and monitoring of urinary tract infections (UTIs). The aim of our study is to describe the dynamics of ecDNA in the plasma and urine of patients with urosepsis as well as ...
Michaela Mihaľová, Nadja Šupčíková, Alexandra Gaál Kovalčíková, Ján Breza, Ľubomíra Tóthová, Peter Celec, Ján Breza   +6 more
doaj   +1 more source

CRISPR-CATCH Improves Human ecDNA Profiling in Tumor Tissue [PDF]

Cancer Discovery, 2022
Abstract CRISPR-CATCH allows for improved isolation of megabase-sized ecDNA from cancer cells and patient tissue.

openalex   +2 more sources

Inhibition of novel human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer

Research Square
Extrachromosomal circular DNA (ecDNA) have been found in most types of human cancers, and ecDNA incorporating viral genomes has recently been described, specifically in human papillomavirus (HPV)-mediated oropharyngeal cancer (OPC).
Joseph A. Califano, Takuya Nakagawa, Jens Luebeck, Kaiyuan Zhu, Joshua T. Lange, Roman Šášik, Chad Phillips, Sayed Sadat, Sara Javadzadeh, Qian Yang, Allen Wang, Kersi Pestonjamasp, Sara Brin Rosenthal, Kathleen M. Fisch, Paul S. Mischel, Vineet Bafna   +15 more
openalex   +2 more sources

ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer. [PDF]

, 2018
The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma.
Bafna, Vineet, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Nguyen, Nam-Phuong D   +4 more
core   +1 more source

Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression

Journal of Experimental & Clinical Cancer Research, 2020
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse range of cancers.
Xiang Gu, Jie Yu, Peiwei Chai, Shengfang Ge, Xianqun Fan   +4 more
doaj   +1 more source

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
core   +1 more source

Specific suppression of long terminal repeat retrotransposon mobilization in plants [PDF]

, 2022
The tissue culture passage necessary for the generation of transgenic plants induces genome instability. This instability predominantly involves the uncontrolled mobilization of LTR retrotransposons (LTR-TEs), which are the most abundant class of mobile ...
Adulyanukosol, Natthawut, Brestovitsky, Anna, Catoni, Marco, Cho, Jungnam, Iwasaki, Mayumi, Paszkowski, Jerzy   +5 more
core   +2 more sources

Sequence-independent identification of active LTR retrotransposons in Arabidopsis [PDF]

, 2018
Detection of retrotransposons capable of contemporary transposition is hampered by the replicative nature of their movement and is usually limited to fortuitous observations of new integration events causing visible phenotypes.
Catoni, M, Griffiths, J, Iwaski, M, Paszkowski, J   +3 more
core   +1 more source