Results 71 to 80 of about 2,326 (226)

The dynamics of extracellular DNA associates with treatment response in patients with rheumatoid arthritis

Scientific Reports, 2022
Rheumatoid arthritis (RA) as a chronic autoimmune inflammatory disease increases extracellular DNA (ecDNA). Our previous study has shown that anti-inflammatory treatment reduces ecDNA, but it is unclear whether there is an association with treatment ...
Kristína Macáková, Júlia Illésová, Vanda Mlynáriková, Alexandra Lesayová, Barbora Konečná, Barbora Vlková, Peter Celec, Emöke Šteňová   +7 more
doaj   +1 more source

The induction of Maspin expression by a glucosamine-derivative has an antiproliferative activity in prostate cancer cell lines [PDF]

, 2019
Mammary serine protease inhibitor or Maspin has been characterized as a class II tumor suppressor gene in several cancer types, among them prostate cancer (CaP).
Cocchiola, Rossana, de Santi, Maria Margherita, Eufemi, Margherita, Guazzo, Raffaella, Lopreiato, Mariangela, Scandurra, Roberto, Scotto d'Abusco, Anna   +6 more
core   +2 more sources

Detection of viable Mycobacterium ulcerans in clinical samples by a novel combined 16S rRNA reverse transcriptase/IS2404 real-time qPCR assay. [PDF]

, 2012
Detection of Viable Mycobacterium ulcerans in Clinical Samples by a Novel Combined 16S rRNA Reverse Transcriptase/IS2404 Real-Time qPCR ...
Adjei, O, Amoako, YA, Awua-Boateng, NY, Battke, F, Beissner, M, Bretzel, G, Herbinger, KH, Huber, KL, Jansson, M, Löscher, T, Phillips, RO, Sarfo, FS, Symank, D   +12 more
core   +2 more sources

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells [PDF]

, 2023
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved.
Bei, Yi, Brückner, Lotte, Chamorro González, Rocío, Chang, Howard Y., Conrad, Thomas, Deubzer, Hedwig E., Dorado Garcia, Heathcliff, Eggert, Angelika, Giurgiu, Mădălina, Haase, Kerstin, Helmsauer, Konstantin, Henssen, Anton G., Hung, King L., Kasack, Katharina, Koche, Richard P., Leen, Eric van, Lodrini, Marco, Mundlos, Stefan, Rodriguez-Fos, Elias, Sauer, Sascha, Schmelz, Karin, Schulte, Johannes H., Schwarz, Roland F., Stefanova, Maria E., Stöber, Maja C., Xu, Robin   +25 more
core   +1 more source

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor [PDF]

, 2016
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds
Altschul, Bassham, Baxt, Berrow, Birgisdottir, Boyle, Bozkurt, Bozkurt, Bozkurt, Caillaud, Chaparro-Garcia, Choy, Dagdas, Fisher, Geldner, Hanamata, He, Huang, Ivanov, Kalvari, Karimi, Kumar, Kwon, Lamb, Larkin, Lenz, Li, Lipka, Liu, Lv, Morgan, Mostowy, Oh, Patel, Petre, Randow, Randow, Saunders, Segonzac, Shintani, Song, Stolz, Svenning, Teh, Vanhee, Wang, Win, Yoshimoto, Zientara-Rytter   +48 more
core   +2 more sources

Biological Mechanisms of Gold Nanoparticle Radiosenstitisation [PDF]

, 2017
There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as ...
Butterworth, Karl T., Connolly, Chris, Prise, Kevin M., Rosa, Soraia, Schettino, Giuseppe   +4 more
core   +1 more source

Sequencing of methylase-accessible regions in integral circular extrachromosomal DNA reveals differences in chromatin structure

Epigenetics & Chromatin, 2021
Background Although extrachromosomal DNA (ecDNA) has been intensively studied for several decades, the mechanisms underlying its tumorigenic effects have been revealed only recently. In most conventional sequencing studies, the high-throughput short-read
Weitian Chen, Zhe Weng, Zhe Xie, Yeming Xie, Chen Zhang, Zhichao Chen, Fengying Ruan, Juan Wang, Yuxin Sun, Yitong Fang, Mei Guo, Yiqin Tong, Yaning Li, Chong Tang   +13 more
doaj   +1 more source

Advances in sequencing-based studies of microDNA and ecDNA: Databases, identification methods, and integration with single-cell analysis

Computational and Structural Biotechnology Journal, 2023
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from genomic DNA but are separate from chromosomes. They are common in various organisms, with sizes ranging from a few hundred to millions of base pairs.
Rong Jiang, Manqiu Yang, Shufan Zhang, Moli Huang   +3 more
doaj   +1 more source

New hints towards a precision medicine strategy for IDH wild-type glioblastoma. [PDF]

, 2020
Glioblastoma represents the most common primary malignancy of the central nervous system in adults and remains a largely incurable disease. The elucidation of disease subtypes based on mutational profiling, gene expression and DNA methylation has so far ...
Byrne, A T, Clerkin, J, Connor, K, Golebiewska, A, Idbaih, A, Lamfers, M L M, Murphy, B M, Niclou, S P, O\u27Brien, D, O\u27Farrell, A C, Prehn, J H M, Rehm, M, Salvucci, M, Verhaak, Roel G W, Verreault, M, White, K   +15 more
core   +3 more sources

Revisiting characteristics of oncogenic extrachromosomal DNA as mobile enhancers on neuroblastoma and glioma cancers

Cancer Cell International, 2022
Cancer can be induced by a variety of possible causes, including tumor suppressor gene failure and proto-oncogene hyperactivation. Tumor-associated extrachromosomal circular DNA has been proposed to endanger human health and speed up the progression of ...
Mohsen Karami Fath, Nastaran Karimfar, Andarz Fazlollahpour Naghibi, Shahriyar Shafa, Melika Ghasemi Shiran, Mehran Ataei, Hossein Dehghanzadeh, Mohsen Nabi Afjadi, Tahereh Ghadiri, Zahra Payandeh, Vahideh Tarhriz   +10 more
doaj   +1 more source