Results 71 to 80 of about 2,028 (216)

The role of mobile DNA elements in the dynamics of plant genome plasticity. [PDF]

J Exp Bot
Plants host a range of DNA elements capable of self-replication. These molecules, usually associated to the activity of transposable elements or viruses, are found integrated in the genome or in the form of extrachromosomal DNA.
Emmerson R, Catoni M.
europepmc   +3 more sources

ecDNA amplification of MYC drives intratumor copy-number heterogeneity and adaptation to stress in PDAC

bioRxiv, 2023
Intratumor heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance. Oncogene dosage variation contributes to cell state transitions and phenotypic heterogeneity, thereby providing a substrate for somatic evolution ...
A. Malinova, Daniel Schreyer, Elena Fiorini, Davide Pasini, Michele Bevere, Sabrina D'Agosto, S. Andreani, F. Lupo, L. Veghini, Sonia Grimaldi, S. Pedron, C. Nourse, R. Salvia, G. Malleo, A. Ruzzenente, A. Guglielmi, M. Milella, R. Lawlor, C. Luchini, Christian Pilarsky, Aldo Scarpa, D. Tuveson, Peter Bailey, V. Corbo   +23 more
semanticscholar   +1 more source

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data

Oncogenesis, 2023
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance.
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang   +4 more
doaj   +1 more source

Identification and characterization of extrachromosomal circular DNA in Wei and Large White pigs by high-throughput sequencing

Frontiers in Veterinary Science, 2023
Wei pig (WP) and Large White pig (LP) are fatty and lean breeds, respectively. Extrachromosomal circular DNA (eccDNA) plays an important role in regulating signaling pathway processes of cell. However, there are few reports regarding the eccDNA and ecDNA
Aiyou Wen, Wei Zhang, Jingen Xu, Kunping Wang, Hong Hu   +4 more
doaj   +1 more source

An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor [PDF]

, 2016
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds
Altschul, Bassham, Baxt, Berrow, Birgisdottir, Boyle, Bozkurt, Bozkurt, Bozkurt, Caillaud, Chaparro-Garcia, Choy, Dagdas, Fisher, Geldner, Hanamata, He, Huang, Ivanov, Kalvari, Karimi, Kumar, Kwon, Lamb, Larkin, Lenz, Li, Lipka, Liu, Lv, Morgan, Mostowy, Oh, Patel, Petre, Randow, Randow, Saunders, Segonzac, Shintani, Song, Stolz, Svenning, Teh, Vanhee, Wang, Win, Yoshimoto, Zientara-Rytter   +48 more
core   +1 more source

Comprehensive analysis of clustered mutations in cancer reveals recurrent APOBEC3 mutagenesis of ecDNA [PDF]

, 2021
ABSTRACTClustered somatic mutations are common in cancer genomes with prior analyses revealing several types of clustered single-base substitutions, including doublet- and multi-base substitutions, diffuse hypermutation termed omikli, and longer strand-coordinated events termed kataegis.
Erik N. Bergstrom, Jens Luebeck, Mia Petljak, Vineet Bafna, Paul S. Mischel, Reuben S. Harris, Ludmil B. Alexandrov   +6 more
openaire   +2 more sources

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development

Chinese Journal of Lung Cancer, 2020
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has ...
Yutong WANG, Fan YE, Xiao ZHANG, Ruihan ZOU, Mingyuan WANG, Kai YU, Shiyun CUI   +6 more
doaj   +1 more source

Effect of SARS-CoV-2 Infection and COVID-19 Vaccination on Oxidative Status of Human Placenta: A Preliminary Study

Antioxidants, 2023
Infection with SARS-CoV-2 during pregnancy increases the risk of pregnancy complications associated with inflammation, which could lead to oxidative stress in the placenta. Whether vaccination against COVID-19 has any effect is unclear.
Kristína Macáková, Petra Pšenková, Nadja Šupčíková, Barbora Vlková, Peter Celec, Jozef Záhumenský   +5 more
doaj   +1 more source

New hints towards a precision medicine strategy for IDH wild-type glioblastoma. [PDF]

, 2020
Glioblastoma represents the most common primary malignancy of the central nervous system in adults and remains a largely incurable disease. The elucidation of disease subtypes based on mutational profiling, gene expression and DNA methylation has so far ...
Byrne, A T, Clerkin, J, Connor, K, Golebiewska, A, Idbaih, A, Lamfers, M L M, Murphy, B M, Niclou, S P, O\u27Brien, D, O\u27Farrell, A C, Prehn, J H M, Rehm, M, Salvucci, M, Verhaak, Roel G W, Verreault, M, White, K   +15 more
core   +3 more sources

EGFR, the Lazarus target for precision oncology in glioblastoma [PDF]

, 2022
The Lazarus effect is a rare condition that happens when someone seemingly dead shows signs of life. The epidermal growth factor receptor (EGFR) represents a target in the fatal neoplasm glioblastoma (GBM) that through a series of negative clinical ...
Binder, Zev A, Cloughesy, Timothy F, Furnari, Frank B, Lin, Benjamin, Miller, C Ryan, Nathanson, David A, O’Rourke, Donald M, Skinner, Kasey R, Smithberger, Erin, Zhao, Eva, Ziebro, Julia   +10 more
core   +2 more sources