Results 81 to 90 of about 2,326 (226)

Single‐cell third‐generation sequencing‐based multi‐omics uncovers gene expression changes governed by ecDNA and structural variants in cancer cells

Clinical and Translational Medicine, 2023
Background Cancer cells often exhibit large‐scale genomic variations, such as circular extrachromosomal DNA (ecDNA) and structural variants (SVs), which have been highly correlated with the initiation and progression of cancer.
Lei Chang, Enze Deng, Jun Wang, Wei Zhou, Jian Ao, Rong Liu, Dan Su, Xiaoying Fan   +7 more
doaj   +1 more source

Identification and characterization of extrachromosomal circular DNA in Wei and Large White pigs by high-throughput sequencing

Frontiers in Veterinary Science, 2023
Wei pig (WP) and Large White pig (LP) are fatty and lean breeds, respectively. Extrachromosomal circular DNA (eccDNA) plays an important role in regulating signaling pathway processes of cell. However, there are few reports regarding the eccDNA and ecDNA
Aiyou Wen, Wei Zhang, Jingen Xu, Kunping Wang, Hong Hu   +4 more
doaj   +1 more source

ECCFP: A consecutive full pass‐based bioinformatic analysis for eccDNA identification from long‐read sequencing data

iMetaOmics, EarlyView.
A new bioinformatics pipeline called ECCFP has been developed to improve the detection of extrachromosomal circular DNA (eccDNA) from long‐read sequencing data. ECCFP uses all consecutive full passes from individual reads for candidate eccDNA identification and consolidates candidate eccDNAs to generate accurate unique eccDNA.
Wang Li, Biyuan Miao, Jun Zhang, Qingsong Zeng, Tangxuan Zhang, Zetong Wu, Yusheng Song, Mengting Li, Lilu Guo, Juan Luo, Jingxiang Xu, Tianliang Liu, Shifu Chen, Jia Gu, Shaogui Wan   +14 more
wiley   +1 more source

EGFR, the Lazarus target for precision oncology in glioblastoma [PDF]

, 2022
The Lazarus effect is a rare condition that happens when someone seemingly dead shows signs of life. The epidermal growth factor receptor (EGFR) represents a target in the fatal neoplasm glioblastoma (GBM) that through a series of negative clinical ...
Binder, Zev A, Cloughesy, Timothy F, Furnari, Frank B, Lin, Benjamin, Miller, C Ryan, Nathanson, David A, O’Rourke, Donald M, Skinner, Kasey R, Smithberger, Erin, Zhao, Eva, Ziebro, Julia   +10 more
core   +2 more sources

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

Circlehunter: a tool to identify extrachromosomal circular DNA from ATAC-Seq data

Oncogenesis, 2023
In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified circular DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance.
Manqiu Yang, Shufan Zhang, Rong Jiang, Shaomu Chen, Moli Huang   +4 more
doaj   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Role of extracellular DNA in Candida albicans biofilms [PDF]

, 2009
DNA has been described as a structural component of the extracellular matrix in bacterial biofilms. However, in Candida albicans there is a scarce knowledge concerning the contribution of extracellular DNA (ecDNA) to biofilm matrix and overall ...
Henriques, Mariana, Lopez-Ribot, José L., Martins, Margarida Isabel Barros Coelho, Oliveira, Rosário   +3 more
core  

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription

Nucleic Acids Research, 2023
Human papillomavirus (HPV) integration is a critical step in cervical cancer development; however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly understood. In this study, we employed integrative analysis on multi-omics
R. Tian, Zheying Huang, Lifang Li, Jingping Yuan, Qinghua Zhang, Lirong Meng, Bin Lang, Yongfeng Hong, Chaoyue Zhong, Xun Tian, Zifeng Cui, Zhuang Jin, Jiashu Liu, Zhaoyue Huang, Yuyan Wang, Ye Chen, Zheng Hu   +16 more
semanticscholar   +1 more source