Neuromodulation and the toolkit for behavioural evolution: can ecdysis shed light on an old problem? [PDF]
FEBS JAltered neuromodulatory signalling via GPCRs frequently underlies evolutionary changes in behaviour. GPCRs and their ligands might thus represent a ‘toolkit’ akin to the Evo‐Devo toolkit responsible for animal development. Just as evolutionary changes in the Evo‐Devo toolkit can alter gene regulatory network function and morphology, changes in ...
Sullivan LF +4 more
europepmc +2 more sources
Insight into mosquito GnRH-related neuropeptide receptor specificity revealed through analysis of naturally occurring and synthetic analogs of this neuropeptide family [PDF]
, 2019 Adipokinetic hormone (AKH), corazonin (CRZ), and the AKH/CRZ-related peptide (ACP) are neuropeptides considered homologous to the vertebrate gonadotropin-releasing hormone (GnRH).
Gade, Gerd +2 more
core +1 more source
Effects of flanking sequences and cellular context on subcellular behavior and pathology of mutant HTT [PDF]
, 2020 Huntington’s disease (HD) is caused by an expansion of a poly glutamine (polyQ) stretch in the huntingtin protein (HTT) that is necessary to cause pathology and formation of HTT aggregates.
Agrawal, Namita +10 more
core +2 more sources
Neuropeptidergic Signaling in the American Lobster Homarus americanus: New Insights from High-Throughput Nucleotide Sequencing. [PDF]
PLoS ONE, 2015 Peptides are the largest and most diverse class of molecules used for neurochemical communication, playing key roles in the control of essentially all aspects of physiology and behavior.
Andrew E Christie +7 more
doaj +1 more source
Peptidergic cell-specific synaptotagmins in Drosophila: Localization to dense-core granules and regulation by the bHLH protein dimmed [PDF]
, 2014 Bioactive peptides are packaged in large dense-core secretory vesicles, which mediate regulated secretion by exocytosis. In a variety of tissues, the regulated release of neurotransmitters and hormones is dependent on calcium levels and controlled by ...
Dani, Adish +3 more
core +2 more sources
Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2. [PDF]
PLoS Genetics, 2012 The ecdysone receptor is a heterodimer of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (USP). In Drosophila melanogaster, three EcR isoforms share common DNA and ligand-binding domains, but these proteins differ in their most N ...
Sebastien A Gauthier +4 more
doaj +1 more source
Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest [PDF]
, 2018 Hylobius abietis (Linnaeus), or large pine weevil (Coleoptera, Curculionidae), is a pest of European coniferous forests. In order to gain understanding of the functional physiology of this species, we have assembled a de novo transcriptome of H. abietis,
Davies, Shireen-Anne +7 more
core +1 more source
Corazonin signaling is required in the male for sperm transfer in the oriental fruit fly Bactrocera dorsalis [PDF]
, 2018 Corazonin (Crz) is a widely distributed neuropeptide (or neurohormone) in insects with diverse physiological functions. The present study aimed to reveal the functions of Crz and its receptor (CrzR) in the regulation of sexual behavior and fertility in ...
Chen, Er-Hu +8 more
core +1 more source
Steroid hormone ecdysone deficiency stimulates preparation for photoperiodic reproductive diapause.
PLoS Genetics, 2021 Diapause, a programmed developmental arrest primarily induced by seasonal environmental changes, is very common in the animal kingdom, and found in vertebrates and invertebrates alike.
Shuang Guo +6 more
doaj +1 more source
DINeR: Database for Insect Neuropeptide Research [PDF]
, 2017 Neuropeptides are responsible for regulating a variety of functions, including development, metabolism, water and ion homeostasis, and as neuromodulators in circuits of the central nervous system.
Davies, Shireen-Anne +5 more
core +1 more source