Results 181 to 190 of about 678,002 (383)

PLIN2 Promotes Lipid Accumulation in Ascites‐Associated Macrophages and Ovarian Cancer Progression by HIF1α/SPP1 Signaling

open access: yesAdvanced Science, Volume 12, Issue 12, March 27, 2025.
This study interrogated the single‐cell transcriptome of immune cells across multiple anatomical sites in ovarian cancer patients and identified a novel subset of macrophages that are enriched in ascites and overexpressed the lipid droplet protein PLIN2.
Hui Luo   +20 more
wiley   +1 more source

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

open access: yesAdvanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran   +7 more
wiley   +1 more source

Electret‐Inspired Charge‐Injected Hydrogel for Scar‐Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation

open access: yesAdvanced Science, Volume 12, Issue 13, April 3, 2025.
This study presents an electret‐inspired charge‐injected self‐powered hydrogel (QOSP) for the treatment of second‐degree burn wounds infected with Staphylococcus aureus and Pseudomonas aeruginosa. The hydrogel effectively eliminates bacteria and enhances cell proliferation through electrical stimulation, thereby accelerating wound healing. Additionally,
Mujie Liu   +29 more
wiley   +1 more source

A Novel Protein NAB1‐356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis

open access: yesAdvanced Science, EarlyView.
The circRNA circNAB1 is downregulated in AF patient. Silencing circNAB1 promotes collagen deposition and inflammation, whereas overexpression reduces AF susceptibility. circNAB1 encodes the protein NAB1 356 that interacts with EGR1 to mitigate fibrosis and inflammation.
William W Du   +9 more
wiley   +1 more source

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