Results 201 to 210 of about 678,002 (383)

Multiscale Dissection of Spatial Heterogeneity by Integrating Multi‐Slice Spatial and Single‐Cell Transcriptomics

open access: yesAdvanced Science, Volume 12, Issue 15, April 17, 2025.
Integrating multiple spatial transcriptomics datasets can provide a more comprehensive understanding of tissue structure and cellular heterogeneity. However, batch effects between different slices as well as between spatial transcriptomics and single‐cell reference data bring a great challenge for the integrative analysis.
Yuqi Chen   +4 more
wiley   +1 more source

FREQ‐NESS Reveals the Dynamic Reconfiguration of Frequency‐Resolved Brain Networks During Auditory Stimulation

open access: yesAdvanced Science, EarlyView.
A new analytical pipeline, FREQuency‐resolved Network Estimation via Source Separation (FREQ‐NESS), reveals how the brain at rest is organized in frequency‐specific networks and dynamically rearranges during auditory stimulation. By analyzing source‐reconstructed magnetoencephalography (MEG) data, FREQ‐NESS uncovers the networks' prominence, spatial ...
Mattia Rosso   +6 more
wiley   +1 more source

De-biased Multimodal Electrocardiogram Analysis [PDF]

open access: yesarXiv
Multimodal large language models (MLLMs) are increasingly being applied in the medical field, particularly in medical imaging. However, developing MLLMs for ECG signals, which are crucial in clinical settings, has been a significant challenge beyond medical imaging.
arxiv  

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

open access: yesAdvanced Science, Volume 12, Issue 16, April 24, 2025.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai   +5 more
wiley   +1 more source

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development

open access: yesAdvanced Science, EarlyView.
Box C/D snoRNP complex regulates protein translation. This study identifies ZNHIT3 as a key component of the complex and ensures normal protein expression, including transcription factors orchestrating cell fate commitment, during early mouse embryogenesis.
Guanghui Yang, Qiliang Xin, Jurrien Dean
wiley   +1 more source

Ischemic Area‐Targeting and Self‐Monitoring Nanoprobes Ameliorate Myocardial Ischemia/Reperfusion Injury by Scavenging ROS and Counteracting Cardiac Inflammation

open access: yesAdvanced Science, Volume 12, Issue 11, March 20, 2025.
Myocardial ischemia/reperfusion injury (MIRI) seriously threatens human life, and the corresponding monitoring and treatment require improvement. HI@PSeP‐IMTP, a highly biocompatible probe with advanced self‐monitoring capabilities, enables precise detection of ischemic area distribution and drug release via photoacoustic and fluorescence imaging. This
Xiaobin Ma   +3 more
wiley   +1 more source

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