Results 31 to 40 of about 1,426,858 (213)
An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2
Advanced Science, EarlyView.Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu +7 more
wiley +1 more source
Clinical Case Reports, 2018 Key Clinical Message Cor triatriatum dexter (CTD) is an extremely rare finding (
Dominika Zoltowska +1 more
doaj +1 more source
Echocardiographic diagnosis of sinus Valsalva aneurysm rupture in two pediatric patients
The Turkish Journal of Pediatrics, 1999 Sinus Valsalva aneurysm rupture (SVAR) is a rare cardiac abnormality that requires surgical correction when diagnosed. Previously, cardiac catheterization and angiography were thought to be necessary for its diagnosis.
Funda Öztunç +3 more
doaj +1 more source
The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ
Advanced Science, EarlyView.UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi +6 more
wiley +1 more source
The best of 2005 in echocardiography back from EuroEcho 9 – Florence, Italy
Cardiovascular Ultrasound, 2006 The ninth edition of the congress of the European Association of Echocardiography (EAE) (former working group of Echocardiography) held in Florence has just finished with a great success of participant attendance (2.842) and abstract submissions.
Sicari Rosa
doaj +1 more source
Coexistence of Suspected Tetralogy of Fallot With Absent Pulmonary Valve and Dextrocardia in Pre-Gestational Diabetes Mellitus: A Case Report. [PDF]
Clin Case RepABSTRACT Early fetal echocardiography and serial surveillance are crucial in pregnancies complicated by pregestational diabetes. Tetralogy of Fallot with absent pulmonary valve syndrome may cause progressive cardiomegaly, ventricular hypertrophy, hydrops, and fetal demise.
Golbabaei A, Kahani V, Mousivand M.
europepmc +2 more sources
Advanced Science, EarlyView.Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang +9 more
wiley +1 more source
wcray/R21-doppler: Cardiac_Doppler_Parser
, 2022 First public release of Bossenbroek/Bartlett/Ray/Trask Doppler Echocardiography pre-parser.
Jamie Bossenbroek, wcray
core +1 more source
Advanced Science, EarlyView.A tiny RNA tips the scales of cardiac injury in aging. piR‐4913 recruits OGT to Drp1 and drives its O‐GlcNAcylation at Thr604, promoting excessive mitochondrial fission that aggravates ischemia‐reperfusion injury. Ischemic postconditioning silences this pathway to restore mitochondrial balance and protect the aged myocardium, revealing piR‐4913 as a ...
Xiangyu Zhao +11 more
wiley +1 more source
Dural Sinus Arteriovenous Malformation in the Fetus. Case Report and Discussion of the Literature
Diagnostics, 2021 Sonographic findings of cerebral arteriovenous malformations in the fetus are uncommon and usually regard aneurysm of the Galen vein. Outcome of arteriovenous malformations is usually severe.
Vlasta Fesslova +5 more
doaj +1 more source