Trametinib in Adults with Neurofibromatosis Type 1‐Related Symptomatic Plexiform Neurofibromas
Annals of Neurology, EarlyView.Objective Mitogen‐activated protein kinase kinase inhibitors have shown promising results in treatment of plexiform neurofibromas in neurofibromatosis type 1 patients, but data in adults are limited. The aim of this phase 2 study was to investigate the efficacy and safety of trametinib in adults with neurofibromatosis type 1.
D. Christine Noordhoek +7 more
wiley +1 more source
Gender differences in bicycle exercise stress echocardiography testing
Artery Research, 2018 Background: Sex-specific differences for myocardial infarction and coronary artery disease (CAD) have been reported in several studies. The aim of our present study was to identify gender-specific differences regarding bicycle-exercise-stress ...
Karsten Keller +4 more
doaj +1 more source
Adipocytes in Aortic Stenosis: Association With Clinical and Morphological Indices
Clinical Anatomy, EarlyView.ABSTRACT Recently, great attention has been given to understanding the new pathogenetic mechanisms underlying aortic stenosis (AS). The study aims to understand the role of mature adipocytes in AS and their association with histologic, clinical, and echocardiographic data, an area previously overlooked in AS research.
Elena Zoico +9 more
wiley +1 more source
Arquivos Brasileiros de Cardiologia, 2015 Background: Physical stress echocardiography is an established methodology for diagnosis and risk stratification of coronary artery disease in patients with physical capacity. In obese (body mass index ≥ 30 kg/m2) the usefulness of pharmacological stress
Mara Graziele Maciel Silveira +8 more
doaj +1 more source
Assessment of poststress left ventricular ejection fraction by gated SPECT: comparison with equilibrium radionuclide angiocardiography [PDF]
, 2010 PURPOSE: We compared left ventricular (LV) ejection fraction obtained by gated SPECT with that obtained by equilibrium radionuclide angiocardiography in a large cohort of patients.
ACAMPA, WANDA +8 more
core
Right Heart Remodeling in Patients with End-Stage Alcoholic Liver Cirrhosis: Speckle Tracking Point of View [PDF]
, 2019 BACKGROUND: Data regarding cardiac remodeling in patients with alcoholic liver cirrhosis are scarce. We sought to investigate right atrial (RA) and right ventricular (RV) structure, function, and mechanics in patients with alcoholic liver cirrhosis.
Braun, Alexander +8 more
core +1 more source
Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet +4 more
wiley +1 more source
Echo Research and Practice, 2019 Stress echocardiography is an established technique for assessing coronary artery disease. It has primarily been used for the diagnosis and assessment of patients presenting with chest pain in whom there is an intermediate probability of coronary artery ...
Richard P Steeds +7 more
doaj +1 more source
Arterial Hypertension and Cardiopulmonary Function: The Value of a Combined Cardiopulmonary and Echocardiography Stress Test. [PDF]
High Blood Press Cardiovasc Prev, 2022 Del Punta L +14 more
europepmc +1 more source
The clinical pharmacology of intranasal l-methamphetamine. [PDF]
, 2008 BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom +6 more
core +2 more sources