Results 111 to 120 of about 369,424 (313)

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Recommendations for echocardiography use in the diagnosis and management of cardiac sources of embolism

, 2010
Embolism of cardiac origin accounts for around 15–30% of ischaemic strokes. Strokes due to cardioembolism are generally severe and early and long-term recurrence and mortality are high.
Flachskampf, Frank,, Ringelstein, E. Bernd,, Nihoyannopoulos, Petros,, Sicari, Rosa, Pepi, Mauro, Nihoyannopoulos, Petros, Pepi, Mauro,, Zamorano, Jose,, Flachskampf, Frank, Athanassopoulos, Giorgios, Habib, Gilbert,, Sicari, Rosa,, Ringelstein, E. Bernd, Colonna, Paolo, Zamorano, Jose, Athanassopoulos, Giorgios,, Habib, Gilbert, Colonna, Paolo,, Evangelista, Arturo, Evangelista, Arturo,   +19 more
core   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Redundant Mitral Valve Simulating an Intracardiac Mass on Transesophageal Echocardiography

, 1994
Cardiac ultrasound is a useful diagnostic modality for the evaluation of cardiac masses and tumors. However, normal cardiac structures and normal variants can mimic masses with both transthoracic echocardiography and transesophageal echocardiography.
BAUERLEIN, E. JOSEPH, HOWARD J. WILLENS, RALPH LEVY, CHAKKO, SIMON, E. JOSEPH BAUERLEIN, WILLENS, HOWARD J, KESSLER, KENNETH M, KENNETH M. KESSLER, LEVY, RALPH, SIMON CHAKKO   +9 more
core   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Four-Dimensional Speckle Tracking Echocardiography in Patients with Hypertrophic Cardiomyopathy

, 2015
Objective Abnormal left ventricular (LV) deformational mechanics have been demonstrated in patients with hypertrophic cardiomyopathy (HCM) using two-dimensional (2D) speckle tracking echocardiography, but there is not enough information about the four ...
Kucukoglu, Serdar, Baydar, Onur, Coskun, Ugur, Kilickesmez, Kadriye Orta, Bostan, Cem   +4 more
core   +1 more source

Clinical Anatomy of the Left and Right Atrial Appendages in Humans: Comparative and Developmental Perspective

Clinical Anatomy, EarlyView.
ABSTRACT Human atrial chambers derive from distinct embryonic anlagens, the original embryonic atria gradually transforming into the so‐called auricles, or atrial appendages. This study quantifies macroscopic variations in pectinate muscle architecture in human atrial appendages and evaluates their visualization using clinical imaging modalities.
Markéta Lexová, Caroline Neradilová, Jan Kovanda, Jan Burkert, Jiří Beneš Jr., Martin Bartos, Theodor Adla, Vojtech Melenovsky, Alena Kvasilova, Ondrej Fabian, Ondrej Naňka, David Sedmera   +11 more
wiley   +1 more source

Characterization of blood-filled cyst by contrast echocardiography and computed tomography

, 2008
Contrast echocardiography has been demonstrated useful for left ventricular opacification and improvement of endocardial border delineation. Another important clinical application of this technique refers to the better characterization of cardiac tumors ...
PINTO, Ibrahim M., MATHIAS JR., Wilson, TSUTSUI, Jeane Mike, POMMERANTZEFF, Pablo, ROCHITTE, Carlos Eduardo   +4 more
core   +1 more source

Validation of an Automated Artificial Intelligence‐Driven Planner for Transcatheter Aortic Valve Replacement

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Preprocedural planning with multislice computed tomography (MSCT) is an essential prerequisite for successful transcatheter aortic valve replacement (TAVR). However, preprocedural planning is time‐consuming and may contain clinically meaningful interobserver variability.
Mark M. P. van den Dorpel, Lucas Uchoa de Assis, Jenna van Niekerk, Sophie Deckx, Matthew Sherman, Janelle Schrot, Anna Kozak, Isabella Kardys, Alexander Hirsch, Joost Daemen, Rutger Jan Nuis, Nicolas M. Van Mieghem   +11 more
wiley   +1 more source