Results 1 to 10 of about 6,668 (141)

Tissue-resident macrophage and dendritic cells drive type I IFN immunity to enteroviruses in the liver. [PDF]

PLoS Pathogens
Enteroviruses are major causes of neonatal morbidity and mortality, with echovirus infections commonly associated with severe disease, including acute liver failure.
Emma Heckenberg, Jacob G Davis, Caitlin Hale, Carolyn B Coyne   +3 more
doaj   +2 more sources

Complete-Genome Analysis of Echovirus-30 Isolated from an Encephalitis Case in India Revealed Distinct Mutations [PDF]

Microorganisms
Echovirus 30 (E-30), a member of the Enterovirus B species, is frequently linked to neurological illnesses such as aseptic meningitis, encephalitis, and hand, foot, and mouth disease. In this study, we present the complete-genome analysis of an Echovirus
Rishabh Waghchaure, Jithin Kunjumon, Alfia Fathima Ashraf, Ranjana Mariyam Raju, Anita Shete, Sarah Cherian, Mallika Lavania   +6 more
doaj   +2 more sources

Two dramatically different clinical scenarios of neonatal Echovirus-11 infection in late preterm male twins: a case report and review of the literature [PDF]

Italian Journal of Pediatrics
Background Enterovirus is a well-known cause of infection in all age groups, with particular importance for neonates with both vertically and horizontally transmission.
Simona Perniciaro, Caterina Proietti, Angela Bossi, Roberta Maragliano, Carla Facco, Federica Novazzi, Nicasio Mancini, Massimo Agostino Agosti   +7 more
doaj   +2 more sources

The Meningitis and Encephalitis Registry of Lower Saxony, Germany (MERIN) – design and main results of circulating neurotropic pathogen surveillance, 2003 to 2023 [PDF]

Eurosurveillance
BACKGROUND The Meningitis and Encephalitis Registry in Lower Saxony (MERIN), introduced in 2003, monitors circulating neurotropic pathogens in Lower Saxony and Bremen and offers free laboratory diagnostics for patients hospitalised with aseptic ...
Sophie Rettenbacher-Riefler
doaj   +2 more sources

Circulated echovirus 18 strains in Guangdong Province and worldwide: A novel perspective on genetic diversity and recombination patterns [PDF]

Virulence
Echovirus 18 (E18) has re-emerged as a global public health concern in recent years because of its association with severe neonatal systemic diseases that pose a risk of high mortality.
Zhiyu Li, Xiaohan Yang, Ru Bai, Ping Li, Yanting Qin, Mingyong Luo   +5 more
doaj   +2 more sources

Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development [PDF]

Nature Communications
The pathogenesis of enteric viral infections is attributed to both viral replication and the resultant immune-inflammatory response. To recapitulate this complex pathophysiology, we engineer macrophage-augmented organoids (MaugOs) by integrating human ...
Guige Xu, Jiangrong Zhou, Kuan Liu, Yining Wang, Theano Tsikari, Fang Qin, Francijna van den Hil, Patrick P. C. Boor, Ibrahim Ayada, Annemarie C. de Vries, Jiajing Li, Shijin Jiang, Dewy M. Offermans, Denis E. Kainov, Harry L. A. Janssen, Maikel P. Peppelenbosch, Marcel J. C. Bijvelds, Wenshi Wang, Valeria V. Orlova, Qiuwei Pan, Pengfei Li   +20 more
doaj   +2 more sources

Human FcRn expression and Type I Interferon signaling control Echovirus 11 pathogenesis in mice.

PLoS Pathogens, 2021
Neonatal echovirus infections are characterized by severe hepatitis and neurological complications that can be fatal. Here, we show that expression of the human homologue of the neonatal Fc receptor (hFcRn), the primary receptor for echoviruses, and ...
Alexandra I Wells, Kalena A Grimes, Kenneth Kim, Emilie Branche, Christopher J Bakkenist, William H DePas, Sujan Shresta, Carolyn B Coyne   +7 more
doaj   +1 more source

Echovirus induces autophagy to promote viral replication via regulating mTOR/ULK1 signaling pathway

Frontiers in Immunology, 2023
Among enteroviruses, echovirus can cause severe illnesses in neonates or infants, with high morbidity and mortality. Autophagy, a central component of host defense mechanisms, can function against diverse infections. In the present study, we investigated
Chunchen Wu, Luzhi Zeng, Luzhi Zeng, Wenfu Yi, Yuanjiu Miao, Yihan Liu, Yihan Liu, Qiming Wang, Shi Liu, Guoping Peng, Zhenhua Zheng, Jianbo Xia   +11 more
doaj   +1 more source

Early Entry Events in Echovirus 30 Infection [PDF]

Journal of Virology, 2020
Echovirus 30 (E30) is a prevalent enterovirus causing regular outbreaks in both children and adults in different parts of the world. It is therefore surprising that relatively little is known of its infectious entry pathway. We set out to generate a cDNA clone and gradient purified the virus in order to study the early entry events in human cells.
Vandesande, Helena, Laajala, Mira, Kantoluoto, Tino, Ruokolainen, Visa, Lindberg, A. Michael, Marjomäki, Varpu   +5 more
openaire   +4 more sources

Enterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract

mBio, 2022
Enteroviruses are among the most common viral infectious agents of humans and cause a broad spectrum of mild-to-severe illness. Enteroviruses are transmitted primarily by the fecal-oral route, but the events associated with their intestinal replication ...
Alexandra I. Wells, Kalena A. Grimes, Carolyn B. Coyne   +2 more
doaj   +1 more source