Results 131 to 140 of about 212,448 (296)

Electroacupuncture Improves the Learning and Memory by Modulating Hippocampal Glucose Metabolism through IGF1/IGF1R Signaling in Alzheimer's Disease

Advanced Science, EarlyView.
Electroacupuncture (EA) ameliorates learning and memory function in 5×FAD mice by regulating the brain glucose metabolic network. This neuroprotective effect is closely related to enhancing neuronal energy utilization via the IGF1/IGF1R signaling pathway.
Shengxiang Liang, Qingqing Zhang, Xiuxiu Wang, Lixin Peng, Xinru Ji, Jiawei Wang, Yusi Zhang, Jiayang Huang, Junchao Yang, Shiqi Zhan, Yiping Xiao, Weilin Liu, Lidian Chen   +12 more
wiley   +1 more source

LUOTTOPROSESSIN TEHOKKUUS JA ECL-LASKELMAN PARAMETRIT: ASIAKASRATINGIN VAIKUTUS ODOTET TUUN LUOTTOTAPPIOON [PDF]

Tässä tutkimuksessa tarkasteltiin luottoprosessin tehokkuutta ja erityisesti Expected Credit Loss (ECL) -mallin kykyä ennustaa luottotappioita. Tutkimuksen keskiössä oli asiakasratingin (PD-luku) vaikutus luottotappioiden ennustamiseen.
Weckström, Matias
core  

SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials.

, 2016
Spinal muscular atrophy (SMA) is caused by defects in the survival motor neuron 1 (SMN1) gene that encodes survival motor neuron (SMN) protein. The majority of therapeutic approaches currently in clinical development for SMA aim to increase SMN protein ...
Nicole Risher, Sergey Paushkin, Taylor, Shannon, Karen S Chen, Phillip Zaworski, Zaworski, Phillip, Weetall, Marla, Marla Weetall, Shannon Taylor (1330992), Katharine M von Herrmann, McCarthy, Kathleen, Sara S. Sunshine (2556703), Newcomb, Tara, Tara Newcomb (2556706), Prior, Thomas W, Kathryn J Swoboda, von Herrmann, Katharine M, Chen, Karen S, Marla Weetall (1834063), Thomas W. Prior (214821), Tara Newcomb, Sunshine, Sara S, Katharine M. von Herrmann (2556712), Karen S. Chen (114604), Kathryn J. Swoboda (167805), Nicole Risher (2556709), Swoboda, Kathryn J, Sara S Sunshine, Thomas W Prior, Kathleen McCarthy (397776), Risher, Nicole, Phillip Zaworski (114576), Shannon Taylor, Paushkin, Sergey, Kathleen McCarthy, Sergey Paushkin (814065)   +35 more
core   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

YOLOECL a lightweight model for blood cell detection in intelligent medical testing equipment

Discover Artificial Intelligence
Accurate and efficient blood cell detection in microscopic images remains challenging due to dense object distribution, frequent occlusion, and the small size of platelets, which often lead to missed detections and redundant computations in existing ...
Enqiang Liang, Can Zhong, Huimin Lv, Haiying Sun, Shengtao Li, Minghui Zheng   +5 more
doaj   +1 more source

ECL: Class-Enhancement Contrastive Learning for Long-tailed Skin Lesion Classification

, 2023
Skin image datasets often suffer from imbalanced data distribution, exacerbating the difficulty of computer-aided skin disease diagnosis. Some recent works exploit supervised contrastive learning (SCL) for this long-tailed challenge.
Wang, Ke, Xie, Fengying, Chen, Jianqi, Zhang, Yilan   +3 more
core  

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Essays on the Expected Credit Loss Model

The implementation of the Expected Credit Loss (ECL) model represents a significant change in financial reporting for banks by requiring the recognition of loan loss provisions based on expected credit losses at loan origination. This thesis examines the
Dejuan Bitria, Daniel
core   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Nitric Oxide administration during extracorporeal life support (ECLS) in different experimental models

, 2023
Nitric oxide when delivered intro the cardiopulmonary bypass circuit seems to improves cardiac function and attenuate inflammation in experimental models of ...
openaire   +1 more source