Results 161 to 170 of about 308,092 (299)

Default Prediction Using the Cox Regression Model and Macroeconomic Conditions – A Lifetime Perspective

Ekonometria
Aim: Since the implementation of International Financial Reporting Standards 9 (IFRS 9), several techniques on estimating the risk parameters for calculating the expected credit losses (ECL) have been implemented across financial institutions.
Aneta Ptak-Chmielewska, Juan Pablo Espinosa Gonzalez   +1 more
doaj  

The impact of system interaction quality on learning outcomes in online virtual experiment teaching: the mediating role of extraneous cognitive load. [PDF]

Front Psychol
Yin P, Sun T.
europepmc   +1 more source

Metabolic Regulation of Dimethylsulfoniopropionate Cleavage and Dimethyl Sulfide Production in Halomonas sp. D47

Advanced Science, EarlyView.
Dimethylsulfoniopropionate (DMSP) is a major marine organosulfur compound central to climate‐relevant dimethyl sulfide (DMS) production. In Halomonas sp. D47, DMSP catabolism is revealed to be coordinated by two transcriptional regulators, AcuR and AcuZ, which control gene expression by sensing DMSP and its metabolites.
Li‐Yuan Zheng, Wen‐Xin Jiang, Xiao‐Meng Sun, Li Liu, Zhao‐Jie Teng, Hou‐Qi Wang, Wen‐Jing Zhu, Chang Ge, Qi‐Long Qin, Ning‐Hua Liu, Hai‐Yan Cao, Hui‐Hui Fu, Chun‐Yang Li, Jonathan D. Todd, Xiu‐Lan Chen, Yu‐Zhong Zhang, Peng Wang   +16 more
wiley   +1 more source

Redox-mediator enhanced electrochemiluminescence under non-aqueous conditions. [PDF]

Chem Sci
Blom SJ, Mesgari F, Martin EMS, Doeven EH, Hayne DJ, Connell TU, Barnard PJ, Saeedizadeh N, Jalali SMJ, Francis PS.   +9 more
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Progress in Machine Learning-Assisted Biosensors for Alzheimer's Disease. [PDF]

Biosensors (Basel)
Feng Y, Chen C.
europepmc   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Exploring the Feasibility of Paper-Based Substrates for User-Friendly Electrochemiluminescent Sensors. [PDF]

Anal Chem
Kalligosfyri PM, Scognamiglio L, Sossich E, Cheng N, Polo F, Cinti S.   +5 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

The Synthesis of Ru-Co-Oxalate MOFs for an Electrochemiluminescent Glyphosate Sensor. [PDF]

Biosensors (Basel)
Espinosa-Cavazos KG, Rodríguez-Hernández J, Gallardo-Vega C, Alvarado-Canché C, Castillo MA, Torres-Lubian R, Casillas PEG, Anaya-Zavaleta JC, Ledezma-Pérez A, León A.   +9 more
europepmc   +1 more source