Results 51 to 60 of about 87,735 (302)

Effects of sirtuin 1 deficiency on trophoblasts and its implications in the pathogenesis of pre-eclampsia

, 2023
Sirtuin 1 (SIRT1) is mainly localised in syncytiotrophoblasts and cytotrophoblasts, and is involved in pregnancy regulation. However, data on the association between SIRT1 and pre-eclampsia (PE) remains limited.
Ping Du (328871), Ling Chen (25698), Xianping Liu (1657897), Hongbiao Yu (9544280), Ying Xia (222301)   +4 more
core   +1 more source

GRIA2 Variant Associated With Paradoxical Response to Perampanel Expanding the Spectrum of GRIA2‐Related Epileptic Encephalopathy: Case Report and Literature Review

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata, Chhitij Tiwari, Zheng Fan, Muge Gucsavas‐Calikoglu, Yael Shiloh‐Malawsky, Kimberly S. Foss, Stephanie N. Peck, Erin L. Heinzen, Chon Lee, Senyene E. Hunter   +9 more
wiley   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Health and Economic Impacts of an Early Labor Induction Policy for High‐BMI Mothers

Health Economics, EarlyView.
ABSTRACT We expand the literature on marginal returns to birth interventions by studying a common intervention: early induction of labor for a growing share of pregnancies, high‐Body Mass Index (BMI) women. We exploit Danish guidelines which recommend routine induction at 7 days after the expected due date instead of 10–13 days after for mothers with a
Louis Freget, Maria Koch Gregersen
wiley   +1 more source

Pre-eclampsia

, 2023
Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia have reduced life expectancy, with increased risks of stroke, cardiovascular ...
Nicolaides, Kypros H., Ellen Menkhorst, Wei Zhou, Hyett, Jon A. (R20572), Rolnik, Daniel L., Whitehead, Clare, Costa, Fabricio da Silva, Kaori Koga, Fabricio da Silva Costa, Rossana P. V. Francisco, Evdokia Dimitriadis, Kypros Nicolaides, Estrada-Gutierrez, Guadalupe, Daniel L. Rolnik, Francisco, Rossana P., Zhou, Wei, Clare Whitehead, Guadalupe Estrada-Gutierrez, Koga, Kaori, Francisco, Rossana PV, Nicolaides, Kypros, Rolnik, Daniel L, Dimitriadis, Evdokia, Hyett, Jon, Jon Hyett, Menkhorst, Ellen   +25 more
core   +1 more source

Preterm and term pre-eclampsia: relative burdens of maternal and perinatal complications. [PDF]

, 2022
To determine the relative burdens of maternal and perinatal complications, for preterm and term pre-eclampsia. Prospective observational cohort study. Two English maternity units.
Akolekar, R., von Dadelszen, P., Syngelaki, Argyro, Nicolaides, Kypros H, Magee, L.   +4 more
core   +1 more source

Is Less More? An Update on Aspirin for Cancer Prevention in Lynch Syndrome From the Cancer Prevention Programme—CaPP

International Journal of Cancer, EarlyView.
ABSTRACT Aspirin has been used to treat pain and fever for 120 years. Its uses expanded into treating arthritis and prevention of thrombotic events. Its anti‐cancer role emerged with observational studies in the 1980's and subsequent cancer review in those treated with aspirin in cardiovascular trials.
John Burn, D. Timothy Bishop
wiley   +1 more source

Trends in the incidence of pre-eclampsia and eclampsia in Taiwan between 1998 and 2010

Taiwanese Journal of Obstetrics & Gynecology, 2015
Objective: The aim of our study was to determine the relationship between age and the incidence of pre-eclampsia and eclampsia. Materials and Methods: We analyzed data collected by the National Health Insurance Bureau between 1998 and 2010.
Te-Fu Chan, Yi-Ching Tung, Shih-Han Wang, Chien-Hung Lee, Chih-Lung Lin, Peih-Ying Lu   +5 more
doaj   +1 more source

Symptoms of Imminent Eclampsia Among Women Attending Care at Muhimbili National Hospital: A Case Refferent Study [PDF]

, 2011
Preeclampsia affects about 5 to 10% of all pregnancies and eclamptic seizure is one of its serious complications. In many developing countries including Tanzania, maternal and perinatal mortality due to eclampsia are high.
France, John
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