Results 191 to 200 of about 2,521,556 (294)

No simple answers for ecological immunology: relationships among immune indices at the individual level break down at the species level in waterfowl

open access: yesProceedings of the Royal Society of London. Biological Sciences, 2006
K. D. Matson   +4 more
semanticscholar   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

open access: yesBrain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová   +19 more
wiley   +1 more source

The Pathological Roles of Cationic Amino Acid Transporters (CATs) in Cancer

open access: yesCancer Science, EarlyView.
CAT family transporters (SLC7A1–SLC7A4) coordinate arginine allocation within the tumor microenvironment, thereby regulating cancer metabolism, mTORC1 signaling, immune responses, and metastatic progression. Emerging evidence supports context‐dependent roles for SLC7A1–SLC7A3, whereas the physiological and pathological functions of SLC7A4 remain poorly
Thant Thant Myo Oo, Yasuhiro Saito
wiley   +1 more source

Proportion of Screen‐Detected Gastrointestinal Cancers From the National Cancer Registry in Japan

open access: yesCancer Science, EarlyView.
Using the data from the Japanese National Cancer Registry, screen‐detected gastrointestinal cancers accounted for roughly 20% of all detected routes. We also found that the proportion of screen‐detected cancers was positively correlated with screening participation rates, supporting screen‐detected cancer proportion as a valuable indicator for ...
Ryuji Okamoto   +6 more
wiley   +1 more source

Spatiotemporal CD8+ T‐Cell Dynamics: Clonal Replacement and Expansion as Determinants of Sustainable Antitumor Response

open access: yesCancer Science, EarlyView.
Durable antitumor immunity depends on continuous clonal replacement: immune checkpoint inhibitors that drive sustainable, polyclonal mobilization of T‐cell clones from tumor‐draining lymph nodes sustain tumor control, whereas limited, oligoclonal mobilization allows pre‐existing clones to become exhausted, leading to immune escape.
Satoshi Ueha   +4 more
wiley   +1 more source

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