Results 61 to 70 of about 2,521,556 (294)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Ecological Immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences

Parasitology, 2009
SUMMARY There has been a recent shift in the literature on mosquito/Plasmodium interactions with an increasingly large number of theoretical and experimental studies focusing on their population biology and evolutionary processes.
Frédéric Tripet
semanticscholar   +1 more source

Editorial: "AAV Gene Therapy: Immunology and Immunotherapeutics" [PDF]

, 2021
Editorial on the Research Topic: AAV Gene Therapy: Immunology and ...
Gao, Guangping, Paulk, Nicole K, Martinez-Navio, José M   +2 more
core   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Frontiers in Clinical Immunology 2008

, 2009
In recent years, investigations in immunology have led to progress in clinical medicine, including understanding transplant rejection, autoimmune diseases, immune deficiencies, inflammation, transplantation, cancer and the development of new vaccines. At
Deniz, G., Zouali, M., Oral, H. B.
core   +2 more sources

Effect of Acute Hypoxia on the Functional State of Erythrocytes and Hemoglobin in Black Scorpionfish [PDF]

Journal of Stress Physiology & Biochemistry, 2023
In the present work the influence of hypoxia on black scorpionfish (Scorpaena porcus) nucleated red blood cells has been studied at in vivo (whole blood) and in vitro (cell suspension) experiments.
Aleksander A. Soldatov, Aleksandra Y. Andreyeva, Tatyana A. Kukhareva, Ekaterina S. Kladchenko   +3 more
doaj  

Increased volume of cerebral oedema is associated with risk of acute seizure activity and adverse neurological outcomes in encephalitis – regional and volumetric analysis in a multi-centre cohort

BMC Neurology, 2022
Background Seizures can occur unpredictably in patients with acute encephalitis syndrome (AES), and many suffer from poor long-term neurological sequelae.
A. M. Alam, J. P. K. Chen, G. K. Wood, B. Facer, M. Bhojak, K. Das, S. Defres, A. Marson, J. Granerod, D. Brown, R. H. Thomas, S. S. Keller, T. Solomon, B. D. Michael   +13 more
doaj   +1 more source

The HCV Envelope Glycoprotein Down-Modulates NF-κB Signalling and Associates With Stimulation of the Host Endoplasmic Reticulum Stress Pathway

Frontiers in Immunology, 2022
Following acute HCV infection, the virus establishes a chronic disease in the majority of patients whilst few individuals clear the infection spontaneously.
Lindsay G. A. McKay, Jordan Thomas, Wejdan Albalawi, Antoine Fattaccioli, Marc Dieu, Alessandra Ruggiero, Jane A. McKeating, Jonathan K. Ball, Alexander W. Tarr, Patricia Renard, Patricia Renard, Georgios Pollakis, William A. Paxton   +12 more
doaj   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source