Results 91 to 100 of about 1,323,788 (296)

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Phylogenetic Niche Conservatism, Phylogenetic Signal and the Relationship between Phylogenetic Relatedness and Ecological Similarity among Species

, 2008
Ecologists are increasingly adopting an evolutionary perspective, and in recent years, the idea that closely related species are ecologically similar has become widespread. In this regard, phylogenetic signal must be distinguished from phylogenetic niche
Jonathan B. Losos, Losos, Jonathan
core   +1 more source

The role of edaphic environment and climate in structuring phylogenetic pattern in seasonally dry tropical plant communities [PDF]

, 2015
This study was made possible through the kind financial support of the São Paulo Research Foundation - http://fapesp.br/en (Fundação de Amparo à Pesquisa do Estado de São Paulo - Fapesp 2013/15280-9).Seasonally dry tropical plant formations (SDTF) are ...
Marcelo Freire Moro, Fernando Roberto Martins (709387), Freire Moro, M., Martins, Fernando Roberto, Fernando Roberto Martins, NIc Lughadha, Eimear, Soares de Araújo, F., Marcelo Freire Moro (5662525), Moro, Marcelo Freire, Thomas R Meagher, Aurélio Silva, I., Roberto Martins, F., Meagher, T. R., Silva, Igor Aurélio, Francisca Soares de Araújo (627635), Nic Lughadha, E. M., Araújo, Francisca Soares de, Francisca Soares de Araújo, Eimear Nic Lughadha, Thomas R. Meagher (420346), Meagher, Thomas Robert, Igor Aurélio Silva, Eimear Nic Lughadha (709386), Igor Aurélio Silva (709385)   +23 more
core   +1 more source

Generalism vs. specialization: Does niche breadth influence species responses to anthropogenic land-use change in Neotropical leaf-cutter ants?

PLoS ONE
Land-use change, such as the transformation of woody ecosystems into open pastures, acts as a strong ecological filter, favouring some species while excluding others according to differences in ecological niche breadth.
Diego Garcia Castillo
doaj   +1 more source

Global warming decreases the morphological traits of germination and environmental suitability of Dipteryx alata (Fabaceae) in Brazilian Cerrado

Acta Botânica Brasílica
We experimentally evaluated how different temperatures affect germination of individual seedlings of Dipteryx alata, and estimated the impact of climate change on the species using ecological niche modeling. A total of 240 seeds were randomly distributed
Raquel Menestrino Ribeiro, Geizianne Tessarolo, Thannya Nascimento Soares, Itamar Rosa Teixeira, João Carlos Nabout   +4 more
doaj   +1 more source

Unveiling the Taxonomic Diversity and Unprecedented Biosynthetic Treasure of the Phylum Myxococcota

Advanced Science, EarlyView.
Natural products remain vital sources of therapeutics, and the phylum Myxococcota constitutes an especially rich reservoir for them. Based on decades of microbiological efforts, we present 154 new Myxococcota genomes and revise taxonomy quadrupling the number of families and genera.
Amay Ajaykumar Agrawal, Ronald Garcia, Guangyi Chen, Chantal D. Bader, Peter Sullivan, Alexander Popoff, Daniel Krug, Maja Hunter, Sebastian Walesch, Emilia Oueis, Christine Frank, Haowen Zhao, Joachim J. Hug, Sebastian Keller, Pascal Hirsch, Azat Tagirdzhanov, Tatiana Malygina, Mary Victory E. Gutierrez, Alexey Gurevich, Judith Boldt, Boyke Bunk, Jörg Overmann, Ulrich Nübel, Andreas Keller, Olga V. Kalinina, Rolf Müller   +25 more
wiley   +1 more source

A Microcapsule‐Integrated smRandom‐seq Platform Enables Fixation‐Free Single Microbe RNA Sequencing

Advanced Science, EarlyView.
We developed a microcapsule‐integrated high‐throughput fixation‐free single‐microbe RNA‐seq workflow in which microbes are encapsulated in aqueous two‐phase microcapsules for physical confinement of nucleic acids. This platform enables co‐encapsulation with barcoded beads for sequencing and reveals that fixation‐free processing enhances transcriptomic ...
Mengdi Song, Yuting Wang, Zhaolun Wang, Shunji Zhang, Zhengmin Tang, Yongcheng Wang   +5 more
wiley   +1 more source

Programmed Interfacial Phase Separation for Spatiotemporal Fungicide Delivery via Tunable Micro/Nano Architectures

Advanced Science, EarlyView.
ABSTRACT Translating dynamic liquid‐liquid phase separation into robust solid‐state architectures remains a challenge in materials engineering. Here, we report a composition‐driven interfacial assembly strategy that couples supramolecular coacervation with metal‐phenolic coordination to engineer tunable fungicide carriers.
Rui Zhang, Tongfang Jing, Leiming He, Kaidi Cui, Yuying Song, Xuewei Mao, Lidong Cao, Lin Zhou   +7 more
wiley   +1 more source

Models of cultural niche construction with selection and assortative mating [PDF]

, 2012
This research was supported in part by National Institutes of Health grant GM28016 and a Biotechnology and Biological Sciences Research Council studentship to LF. The funders had no role in study design, data collection and analysis, decision to publish,
Fogarty, Laurel, Creanza Nicole, Marcus W. Feldman (143724), Laurel Fogarty (143721), Fogarty Laurel, Feldman Marcus W., Laurel Fogarty, Nicole Creanza (143720), Feldman, Marcus W., Creanza, Nicole, Marcus W Feldman, Nicole Creanza   +11 more
core   +2 more sources