Results 71 to 80 of about 14,928,870 (303)

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Ecological Niche Modelling of the Bacillus anthracis A1.a sub-lineage in Kazakhstan

BMC Ecology, 2011
Background Bacillus anthracis, the causative agent of anthrax, is a globally distributed zoonotic pathogen that continues to be a veterinary and human health problem in Central Asia.
Mullins Jocelyn, Lukhnova Larissa, Aikimbayev Alim, Pazilov Yerlan, Van Ert Matthew, Blackburn Jason K   +5 more
doaj   +1 more source

INTEGRATING COALESCENT AND ECOLOGICAL NICHE MODELING IN COMPARATIVE PHYLOGEOGRAPHY [PDF]

Evolution, 2007
Understanding the factors that contribute to the formation of population genetic structure is a central goal of phylogeographic research, but achieving this goal can be complicated by the stochastic variance inherent to genetic processes. Statistical approaches to testing phylogeographic hypotheses accommodate this stochasticity by evaluating competing
Carstens, Bryan C., Richards, Corinne L.
openaire   +3 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Change of niche in guanaco (Lama guanicoe): the effects of climate change on habitat suitability and lineage conservatism in Chile [PDF]

PeerJ, 2018
Background The main goal of this contribution was to define the ecological niche of the guanaco (Lama guanicoe), to describe potential distributional changes, and to assess the relative importance of niche conservatism and divergence processes between ...
Andrea G. Castillo, Dominique Alò, Benito A. González, Horacio Samaniego   +3 more
doaj   +2 more sources

Ecological niche modelling

Current Biology
One of the central research questions in ecology and biogeography revolves around understanding the spatial distribution patterns of organisms, the factors influencing species abundance, and why in certain areas there are more species or individuals than in others.
openaire   +3 more sources

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Ecological niche modeling of rabies in the changing Arctic of Alaska [PDF]

Acta Veterinaria Scandinavica, 2017
Rabies is a disease of global significance including in the circumpolar Arctic. In Alaska enzootic rabies persist in northern and western coastal areas. Only sporadic cases have occurred in areas outside of the regions considered enzootic for the virus, such as the interior of the state and urbanized regions.Here we examine the distribution of ...
Huettmann, Falk, Magnuson, Emily Elizabeth, Hueffer, Karsten   +2 more
openaire   +2 more sources

Species-specific traits plus stabilizing processes best explain coexistence in biodiverse fire-prone plant communities [PDF]

, 2013
Coexistence in fire-prone Mediterranean-type shrublands has been explored in the past using both neutral and niche-based models. However, distinct differences between plant functional types (PFTs), such as fire-killed vs resprouting responses to fire ...
Reineking Björn, Enright, N.J., Jürgen Groeneveld, Enright, Neal, Björn Reineking (113977), Byron B Lamont, Lamont, Byron, Reineking, B., Frank, K., Byron B. Lamont (296799), George L W Perry, Reineking, Bjorn, Neal J. Enright (296801), Karin Frank (211485), Groeneveld, Jurgen, Neal J Enright, Lamont Byron B., Jürgen Groeneveld (416288), George L. W. Perry (416289), Frank Karin, Groeneveld Jürgen, Perry, G.L.W., Perry, George, Lamont, B.B., Perry George L. W., Björn Reineking, Karin Frank, Perry, G., Enright Neal J., Groeneveld, J., Frank, Karin   +30 more
core   +1 more source

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source