Results 201 to 210 of about 1,131,805 (276)

Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides

Angewandte Chemie, EarlyView.
The hypothesized convergent biosynthesis of triculamin‐like lasso peptides from different biosynthetic gene cluster (BGC) types represented across multiple bacterial phyla. The elucidation of the triculamin non‐canonical BGC and resistance mechanism by heterologous expression in Streptomyces albus and in vitro acetylation with resistance conveying ...
Aske Merrild, Tiziana Svenningsen, Marc G. Chevrette, Thomas Tørring   +3 more
wiley   +2 more sources

Krüppel‐like factor 4 transcription factor in blood–brain barrier endothelial cells: A potential role in Alzheimer's disease

Animal Models and Experimental Medicine, EarlyView.
KLF4 (Krüppel‐like factor 4) plays a protective role in blood–brain barrier (BBB). KLF4 plays an ambiguous role in the central nervous system. KLF4 in the BBB endothelial cells could be a potential target for Alzheimer's disease. Abstract Alzheimer's disease is the most prevalent chronic neurodegenerative disorder worldwide, with no sufficient cure ...
Ziying Wei, Chunhua Liu, Jianyu Chen, Yuxiao Yao, Dajiang Qin   +4 more
wiley   +1 more source

In Situ High Selectivity Contact‐Electroreduction of CO2 to Methanol Using an Imine‐Mediated Metal‐Free Vitrimer Catalyst

Angewandte Chemie, EarlyView.
A vitrimer catalyst with C═N bond enables efficient CO2 reduction via contact‐electrocatalysis, driven by water droplet‐induced charges. Imine groups stabilize CO2 adsorption, enrich electrons, and mediate electron transfer, achieving >90% methanol selectivity.
Nannan Wang, Haisong Feng, Jing Yang, Jie Zheng, Yong‐Wei Zhang, Nikos Hadjichristidis, Zibiao Li   +6 more
wiley   +2 more sources

The Comprehensive Roadmap Toward Malaria Elimination Using Graphene and its Promising 2D Analogs

Advanced NanoBiomed Research, EarlyView.
Material based on a diversity of graphene with chemical properties of strong strength, high mobility, high transparency, good heat conductivity, biocompatibility, and chemical stability, advanced devices demonstrating antimalarial characteristics can be used for malaria treatment at different stages of malaria development from the injection of ...
Fangzhou He, George Junior, Rajashree Konar, Yuanding Huang, Ke Zhang, Lijing Ke, Meng Niu, Boon Tong Goh, Amine El Moutaouakil, Gilbert Daniel Nessim, Mohamed Belmoubarik, Weng Kung Peng   +11 more
wiley   +1 more source

Decoding the Chemical Language of Ribosomally Synthesized and Post‐Translationally Modified Peptides from the Untapped Archaea Domain

Angewandte Chemie, EarlyView.
Secondary metabolites (SMs) are essential across all life domains, yet those originating from the Archaea domain remain poorly understood. Here, the systematic genome mining and the pioneering heterologous expression of archaeal SMs have revealed the chemical landscape of archaeal lanthipeptides, showing both canonical and non‐canonical forms.
Zhi‐Man Song, Cunlei Cai, Ying Gao, Xiaoqian Lin, Qian Yang, Dengwei Zhang, Gengfan Wu, Haoyu Liang, Qianlin Zhuo, Junliang Zhang, Peiyan Cai, Haibo Jiang, Wenhua Liu, Yong‐Xin Li   +13 more
wiley   +2 more sources

Towards Polymer Composite‐Based Transient Electronic Systems

Advanced NanoBiomed Research, EarlyView.
Biodegradable electronic systems are gaining attention for implantable biomedical applications, targeting disease treatment and lifespan extension. This review covers advances in biocompatible, biodegradable polymer composites using synthetic and natural polymers with conductive, semiconductive, and insulating fillers.
Gwan‐Jin Ko, Venkata Ramesh Naganaboina, Emad S. Goda, Ankan Dutta, Huanyu Cheng, Suk‐Won Hwang   +5 more
wiley   +1 more source

Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine

Angewandte Chemie, EarlyView.
19E‐geissoschizine is a key precursor in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Using enzymatic assays and gene silencing, three CYPs were identified from C. roseus that oxidize this compound to four alkaloid scaffolds: strychnos, sarpagan, akuammiline, and mavacurane. Mutational analysis reveals
Mohamed O. Kamileen, Benke Hong, Klaus Gase, Maritta Kunert, Lorenzo Caputi, Benjamin R. Lichman, Sarah E. O'Connor   +6 more
wiley   +2 more sources

Succession and dynamics of gorse (Ulex europaeusL.) communities in the dunedin ecological district South Island, New Zealand [PDF]

, 1986
W. G. Lee, R. B. Allen, Peter N. Johnson
openalex   +1 more source

Pure Hydrocarbon Hosts Enabling Efficient Multi‐Resonance TADF Blue‐Emitting Organic Light‐Emitting Diodes

Angewandte Chemie, EarlyView.
The first application of pure hydrocarbon materials as hosts in phosphorescence‐sensitized multi‐resonance thermally activated delayed fluorescence (MR‐TADF) OLEDs is reported. Blue MR‐TADF OLEDs using either DtBuCzB or v‐DABNA as emitter and either FIrpic, fac‐Ir(tpz)3 or CN−Ir as sensitizer, achieved very high maximum external quantum efficiencies ...
Yue‐Jian Yang, Denis Ari, Zhe‐Hong Yu, Kelvine Letellier, Olivier Jeannin, Qi Zheng, Aziz Khan, Cassandre Quinton, Dong‐Ying Zhou, Zuo‐Quan Jiang, Cyril Poriel   +10 more
wiley   +2 more sources

Discovery and Biosynthesis of Celluxanthenes, Antibacterial Arylpolyene Alkaloids From Diverse Cellulose‐Degrading Anaerobic Bacteria

Angewandte Chemie, EarlyView.
The structure and biosynthetic origin of the enigmatic “yellow affinity substance” (YAS) from the anaerobe thermophile Clostridium thermocellum (now: Acetivibrio thermocellus) were elucidated. YAS is a complex of unusual antibacterial arylpolyene alkaloids (celluxanthenes) that are produced by various cellulolytic anaerobes.
Keishi Ishida, Jana Krabbe, Philippe R. Meisinger, Gulimila Shabuer, Sebastian Schieferdecker, Michael Cyrulies, Cedric Tank, Emma Barnes, Christian Paetz, Christian Hertweck   +9 more
wiley   +2 more sources