Results 1 to 10 of about 356,798 (113)

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

open access: yesHepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo   +14 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

open access: yesHepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández   +18 more
wiley   +1 more source

Bifurcation scenarios in an ordinary differential equation with constant and distributed delay: A case study [PDF]

open access: yes, 2018
In this article we consider a model introduced by Ucar in order to simply describe chaotic behaviour with a one dimensional ODE containing a constant delay. We study the bifurcation problem of the equilibria and we obtain an approximation of the periodic
Caraballo Garrido, Tomás   +2 more
core   +2 more sources

La relación inflación-desempleo en la economía española (1964-98): una interpretación [PDF]

open access: yes, 1999
En este artículo analizamos e interpretamos la evolución de la relación inflación-desempleo de la economía española en el período 1964-98, a la luz de las teorías existentes en este área - curva de Phillips tradicional, curva de Phillips ampliada con ...
Gómez García, Francisco   +1 more
core  

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra   +17 more
wiley   +1 more source

Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies

open access: yesChemistry – A European Journal, EarlyView.
The synthesis of multicomponent cancer vaccines on AuNP carriers could be rationalized by the simultaneous functionalization of the antigen and immunomodulator components on the same particles. Immunization with a “diluted” amount of MUC1‐functionalized AuNPs is still capable of eliciting a strong immune response.
Mattia Ghirardello   +8 more
wiley   +1 more source

Dos nuevas aportaciones sobre los aspectos económicos de la Guerra Civil Española [PDF]

open access: yes, 1988
Reseñas de: SANTACREU SOLER, José Miguel: La crisis monetaria española de 1937. Moneda y municipios en la provincia de Alicante durante la guerra civil española, Universidad de Alicante, Alicante, 1986, 182 págs.; GONZÁLEZ PORTILLA, Manuel y GARMENDIA ...
Miranda Encarnación, José Antonio   +1 more
core   +1 more source

Discontinuidades en el crecimiento económico en el periodo 1870-1994: España en perspectiva comparada [PDF]

open access: yes, 2002
La periodización y análisis del proceso de desarrollo de la economía española en el largo plazo es objeto de debate entre un importante grupo de investigadores.
Pons Novell, Jordi, Tirado, Daniel A.
core  

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