Results 151 to 160 of about 519,267 (268)

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

open access: yesBrain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña   +20 more
wiley   +1 more source

Patient‐derived surgical samples reveal the cellular and molecular signatures of glioblastoma infiltration in distinct radiological zones

open access: yesBrain Pathology, EarlyView.
Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios   +18 more
wiley   +1 more source

Patient Stratification for Serum LDH Levels Reveals Distinct CLA<sup>+</sup> T-Cell Cytokine Secretion in Response to HDM, Clinical Features and Allergic Comorbidities. [PDF]

open access: yesInt J Mol Sci
García-Jiménez I   +12 more
europepmc   +1 more source

Terrain Synthesis and Authoring based on Iso‐Contours

open access: yesComputer Graphics Forum, EarlyView.
Abstract Digital terrains are central to realistic landscape depiction, yet authoring tools must balance perceptual realism with intuitive artistic control. We propose a compact vector‐based representation that models terrain as nested iso‐contours, inspired by geomorphology and cartography.
B. Huftier   +5 more
wiley   +1 more source

Differential Effects of Benralizumab and Mepolizumab on Pro‐Resolving Mediators

open access: yes
Allergy, EarlyView.
Jaime Bernaola   +14 more
wiley   +1 more source

Tracking the impact of bottom trawling on benthic habitat status

open access: yesConservation Biology, EarlyView.
Abstract Bottom trawling is the most widespread physical disturbance to marine benthic habitats, yet broadscale assessments of its impact remain limited. We developed a quantitative framework to evaluate trawling effects on benthic habitats at broad spatial scales based on the sentinels of seabed (SoS) indicator.
Maider Plaza‐Morlote   +10 more
wiley   +1 more source

Efficacy of NAMPT Inhibitors in Pancreatic Cancer After Stratification by MAP17 (PDZK1IP1) Levels. [PDF]

open access: yesCancers (Basel)
Verdugo-Sivianes EM   +4 more
europepmc   +1 more source

New insights into the determinants of willingness to pay for supporting professional sport teams

open access: yesContemporary Economic Policy, EarlyView.
Abstract This paper examines the determinants of individuals' willingness to pay (WTP) to prevent the relegation of a professional football team. Drawing on an analytical framework provided by social capital and social identity theories, we hypothesize that social trust and civic pride are key predictors of WTP.
Jaume García   +3 more
wiley   +1 more source

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