Results 61 to 70 of about 10,906,711 (291)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Sustainable Education System in the Face of the COVID-19 Pandemic [PDF]
Ovidius University Annals: Economic Sciences Series, 2020 It is obvious that in this school, but certainly in the next one, the educational system is and will be affected by the evolution of the SARS-CoV-2 epidemic.
Mihaela - Gabriela Todrican (Rosca) +2 more
doaj
Integration of Post‑Communist Countries in the EU –Leaders and Losers?
Comparative Economic Research, 2022 The economic indicators of the new member states of the EU that joined after 2004 have been generally positive. In this paper, we analyse and interpret the economic development results of the 11 new Member States from the Eastern bloc.
Lukáš Cíbik +2 more
doaj +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
The influence of macroeconomic factors to the dynamics of stock exchange in the republic of Kazakhstan [PDF]
Экономика региона, 2016 This article describes the influence of macroeconomic factors on Kazakhstan Stock Exchange Market by using data from 2005 to 2014. Engle-Granger cointegration test has shown that stock index is cointegrated with the exchange rate, interest rate, CPI ...
Shakizada Uteulievna Niyazbekova +2 more
doaj +1 more source
Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
wiley +1 more source
A process of demographic and economic polarization in the Republic of Macedonia [PDF]
Geographica Pannonica, 2013 Demographic and economic development in the Republic of Macedonia is characterized by high dynamics, and imbalance in development. The unequal social and economic development is one of the main negative features of development, especially during the ...
Madzevic Mirjanka +2 more
doaj
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Economic Journal, 2012 We study the short-run and long-run economic impact of one of the largest losses that an individual can face; the death of a child. We utilise unique registers on the entire Swedish population, combining information on the date and cause of death with parental outcomes.
Van den Berg, Gerard +2 more
openaire +7 more sources
Addressing Long-Term Unemployment After The Great Recession: The Crucial Role Of Workforce Training [PDF]
, 2011 [Excerpt] With almost five unemployed workers for every job opening, the economy is not yet creating enough jobs to make a significant reduction in unemployment.
United States Congress Joint Economic Committee
core +1 more source