Results 41 to 50 of about 6,540,809 (302)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Block-level accessibility data for transit-way evaluation in the Twin Cities metropolitan region, 2019

, 2019
The data are provided in 20 shapefiles. The shapefiles are segmented by the scenario comparison and the analysis day/time. The fields include the Census block-level 15-digit identifiers, baseline accessibility, alternative scenario accessibility, their ...
Owen, Andrew, Carlson, Kristin
core   +1 more source

A survey of open accessibility data [PDF]

, 2014
This paper presents the research of using Linked Data for enhancing accessibility data, especially for accessible travelling. With the aim of addressing the gap between users’ special needs and accessibility data, this research initially explores the ...
Ding, Chaohai, Wald, Mike, Gary Wills, Wills, Gary, Chaohai Ding, Mike Wald   +5 more
core   +1 more source

Impact of Socio-Economic Status on Accessibility of Dog Training Classes

Animals, 2019
Behaviour problems are amongst the most common reasons given for relinquishing dogs to rehoming centres. Some behaviour problems may be amenable to being tackled pre-emptively with classes educating owners on basic dog training and understanding ...
Lauren Harris, Tamsin Durston, Jake Flatman, Denise Kelly, Michelle Moat, Rahana Mohammed, Tracey Smith, Maria Wickes, Melissa Upjohn, Rachel Casey   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Analysis on the relationship between accessibility of intercity rail transit and urban economic development

Shenzhen Daxue xuebao. Ligong ban, 2022
As the backbone of regional transportation development, intercity rail transit plays an important role in guiding and driving the economic integration development of Guangdong-Hong Kong-Macao Greater Bay Area (GBA). This paper analyzes and summarizes the
HU Mingwei, WU Wenlin, ZHAO Qian, HE Guoqing   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

SOCIAL PRECARIOUSNESS AND ACCESSIBILITY TO THE URBAN TRANSPORT IN THE MEGACITIES, CASE STUDY OF A PERIPHERAL COMMUNE OF CASABLANCA, MOROCCO [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
The aim of this research is to study the relationship between transportation and poverty. Indeed, the non-existence, lack or weakness of the supply of transport, poor accessibility to the means of transport and thus also to the zones of economic activity
I. Hbiak, I. Hbiak, A. Adidi, E. El Brirchi, J. P. Nicolas   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source