Results 31 to 40 of about 27,819,583 (252)
Oncology and TherapyIntroduction Current treatment guidelines for patients with epidermal growth factor receptor (EGFR)-mutated metastatic non-small cell lung cancer (mNSCLC) recommend EGFR tyrosine kinase inhibitors (TKIs) as the standard of care for first-line treatment ...
Elizabeth Marrett +5 more
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Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Silver lining in the South African land redistribution: lessons from success case studies
Frontiers in Sustainable Food SystemsIntroductionSouth Africa’s land reform programme has generated an extensive body of research documenting widespread underperformance and failure. While this literature has provided important diagnostic insights, considerably less attention has been paid ...
Siphe Zantsi +14 more
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Classification of Building Types in Germany: A Data-Driven Modeling Approach
Data, 2022 Details on building levels play an essential part in a number of real-world application models. Energy systems, telecommunications, disaster management, the internet-of-things, health care, and marketing are a few of the many applications that require ...
Abhilash Bandam +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
LandSouth Africa’s land reform program is a cornerstone of efforts to redress historical injustices, guided by the 1997 White Paper on Land Reform Policy and structured around restitution, redistribution, and tenure reform. Three decades into implementation,
Walter Shiba +9 more
doaj +1 more source
Humanities & Social Sciences Communications, 2023 The main feature of the current business reality is the speed of the changes in the environment and the uncertainty they generate. Among these changes, those which stand out for their importance are the ones related to the current digital revolution ...
Francisco del Olmo-García +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Water resource management and agriculture in the MENA Region: A Spatial Analysis using Geographic Information Systems [PDF]
E3S Web of ConferencesThis article analyzes the spatial contrasts between agriculture and water resources in the MENA region over the period 2000-2022. Using data from the FAO database and calculations of average differences between two periods, several thematic maps were ...
Idalfahim Mohamed, Elouardirhi Saad
doaj +1 more source