Results 61 to 70 of about 453,563 (266)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Artificial Intelligence and Mental Well‐Being in Adult Education: Implications for Practice and Professional Responsibility

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley   +1 more source

IJCM_103A: Cost Benefit Analysis Related to Community Acquired Pneumonia inpatients among Geriatric Age Group-A Study Conducted in A Tertiary Care Hospital

Indian Journal of Community Medicine
Background: Community-acquired pneumonia (CAP) is a common acute infectious disease among elderly people, and is associated with high rates of hospital admission and mortality.
Abhimanyu Behera, Debasish Sethy, Somen Kumar Pradhan, Durga Madhab Satapathy   +3 more
doaj   +1 more source

Consider the economic burden for patients [PDF]

Canadian Medical Association Journal, 2019
I read with interest the commentary by Mr. Matthew Herder and Dr. David Juurlink proposing ministerial recall of high-dose opioid formulations.[1][1] Unquestionably, some “legacy patients” had their opioid doses gradually increased to large doses, but many of these patients have been stable ...
openaire   +2 more sources

Global prevalence and economic and humanistic burden of astigmatism in cataract patients: a systematic literature review

Clinical Ophthalmology, 2018
David F Anderson,1 Mukesh Dhariwal,2 Christine Bouchet,3 Michael S Keith3 1University Hospital Southampton, NHS Foundation Trust, Southampton, UK; 2Novartis Ireland Ltd., Dublin, Ireland; 3Alcon Laboratories Inc., Fort Worth, TX, USA Purpose: To ...
Anderson DF, Dhariwal M, Bouchet C, Keith MS   +3 more
doaj  

Prevalence, incidence, gender and age distribution, and economic burden of psoriasis worldwide and in Kazakhstan [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Aim: This study aimed to conduct a literature review on the prevalence, incidence, gender and age distribution of psoriasis, as well as the economic burden of psoriasis worldwide, including Kazakhstan.
Aidar Dairov, Assel Issabekova, Aliya Sekenova, Miras Shakhatbayev, Vyacheslav Ogay   +4 more
doaj   +1 more source

The socio-economic burden of influenza [PDF]

Journal of Antimicrobial Chemotherapy, 1999
Abstract Influenza epidemics and pandemics have a huge impact on society and individuals. The weight and scope of the burden of influenza varies with the age and underlying health of the patient. The disease imposes a significant burden on all individuals, but hospitalization and treatment occur more frequently in high-risk patients (the
openaire   +4 more sources