Results 41 to 50 of about 7,981,822 (257)
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Fitness centrality: a non-linear centrality measure for complex networks
Journal of Physics: ComplexityAs often happens in science, tools, and methods originally developed in one field can unexpectedly become useful in others. This paper explores the formalism of Economic Fitness Complexity (EFC), initially designed to predict and explain the economic ...
Vito D P Servedio +3 more
doaj +1 more source
Investigating the Asymmetric Effects of Renewable Energy and Economic Complexity on Iran’s Economic Growth within the NARDL Framework [PDF]
Faslnāmah-i Pizhūhish/Nāmah-i IqtisādīAchieving sustainable economic growth and reducing dependence on fossil fuels are strategic priorities for Iran’s economy. Economic complexity—reflecting the technological sophistication and knowledge embedded in production—and renewable energy ...
Fatemeh Sorkhedehi, Priya Kavianinia
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Teaching Complexity and Its Practical Implications in Leadership Development Programs
, 2018 This article describes an advanced leadership seminar for senior managers and executives. The three module seminar describes how thoughtful leaders can learn to succeed even under conditions of extreme complexity. The first module describes complexity in
Hazy, James K, James K Hazy
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Public Administration and Complexity – or how to teach things we can’t predict? [PDF]
, 2018 Introduction to the special issue ‘Teaching ...
Mary Lee Rhodes +3 more
core +1 more source
Revisiting trade openness and economic growth nexus in Africa: The role of economic complexity [PDF]
New Applied Studies in Management, Economics & AccountingThe relationship between trade openness and economic development remains a persistent and conceptually debated issue in international economics. While much of the literature argues that trade openness promotes economic growth, evidence shows this is not ...
Opeyemi Oladunjoye, Rufus Ajisafe
doaj +1 more source
Industrial reconversion in productive clusters. Design and active preservation of local know-how
Agathón, 2021 The discipline of Design is called upon to contribute to the preservation and transmission of the productive culture of agglomeration economies, such as industrial Districts, clusters and networks, a culture threatened by the tendency to move the supply ...
Beatrice Lerma, Eva Vanessa Bruno
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source