Results 71 to 80 of about 1,352,260 (311)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Behavioural Economics: Development, Condition and Perspectives
SSRN Electronic Journal, 2017 The study examines the place of behavioural economics in the structure of economic science and the practice of state regulating. The thesis that neoclassicism is an appropriate normative approach for analysing human behaviour is defended but the comparative advantages are on the side of behavioural economics in the answers of escriptive, diagnostic ...
KANEV, Dimitar, TERZİEV, Venelin
openaire +3 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Scaffolding Success: A Comprehensive Analysis of Cost Management Drivers in Construction Projects
Baltic Journal of Real Estate Economics and Construction ManagementThis research examines the multifaceted factors that influence cost management practices in the Indian construction sector, with the objective of improving efficiency, competitiveness, and sustainability.
Sanchaniya Rashmi Jaymin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
Agricultural Economics (AGRICECON), 2002 In the framework of Slovakia preparation for entering the European Union, there was done a Phare-ACE survey in years 1999-2000. The name of this survey was "Micro-economic analysis of farming households restructuring in pre-accession period to the EU ...
P. Bielik +3 more
doaj +1 more source
Annual report / Economic Policy Council and Office of Economic Policy. [PDF]
, 1987 Consists of articles by various economists on issues of economic policy and reports on economic ...
New Jersey. Economic Policy Council +1 more
core