Results 31 to 40 of about 23,993,779 (341)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Mixed effects modelling of excess mortality and COVID-19 lockdowns in Thailand

open access: yesScientific Reports
Accurate mortality data are critical for understanding the impact of COVID-19 and learning lessons from crisis responses. But published statistics risk misrepresenting deaths due to limited testing, underreporting, and lack of subnational data ...
Anna Christine De Padua Durante   +5 more
doaj   +1 more source

“Knowledge Workers” and Modernization in the Region

open access: yesEconomic and Social Changes: Facts, Trends, Forecast, 2016
Professional education is the main part of personnel training and it serves as the driver of modernization process. “Knowledge workers” are carriers of knowledge provided by the professional training system.
Galina Valentinovna Leonidova   +3 more
doaj   +1 more source

School Improvement Through Strong Leadership [PDF]

open access: yes, 2014
According to the OECD Teaching and Learning International Survey (TALIS), principals, on average, report frequently engaging in a number of activities that are consistent with instructional leadership.
OECD. Organisation for Economic Cooperation and Development
core   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Rural Roads and Local Economic Development

open access: yesThe American Economic Review, 2018
Nearly one billion people worldwide live in rural areas without access to national paved road networks. We estimate the impacts of India’s $40 billion national rural road construction program using a fuzzy regression discontinuity design and ...
S. Asher, P. Novosad
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

ADB–OECD Study on Enhancing Financial Accessibility for SMEs: Lessons from Recent Crises [PDF]

open access: yes, 2014
During the era of global financial uncertainty, stable access to appropriate funding sources has been much harder for small and medium-sized enterprises (SMEs).
Asian Development Bank   +1 more
core   +1 more source

Embedding professional development in schools for teacher success [PDF]

open access: yes, 2015
Teachers report participating in more non-school than school embedded professional development (i.e. professional development that is grounded in teachers daily professional practices).
OECD. Organisation for Economic Cooperation and Development
core   +2 more sources

Women Empowerment and Economic Development

open access: yes, 2012
Women's empowerment and economic development are closely related: in one direction, development alone can play a major role in driving down inequality between men and women; in the other direction, empowering women may benefit development.
E. Duflo
semanticscholar   +1 more source

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