Results 51 to 60 of about 12,022,290 (258)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Estimation and Inclusion of Presenteeism Costs in Applied Economic Evaluation: A Systematic Review. [PDF]

, 2017
OBJECTIVE: Given the significant costs of reduced productivity (presenteeism) in comparison to absenteeism, and overall societal costs, presenteeism has a potentially important role to play in economic evaluations. However, these costs are often excluded.
Lewis
core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Consolidated health economic evaluation reporting standards (CHEERS) statement [PDF]

, 2013
<p>Economic evaluations of health interventions pose a particular challenge for reporting. There is also a need to consolidate and update existing guidelines and promote their use in a user friendly manner.
Mauskopf, Josephine, Moher, D., Don Husereau, Petrou, Stavros, Carswell, Chris, Greenberg, Dan, Augustovski, Federico, Dan Greenberg, Husereau, Donald Robert, Andrew H. Briggs, Federico Augustovski, Petrou, S., Loder, E., Moher, David, Stavros Petrou, Josephine Mauskopf, Elizabeth Loder, Mauskopf, J., Husereau, D., Greenberg, D., Husereau, Don, Carswell, C., Drummond, M., Briggs, A.H., Andrew H Briggs, Chris Carswell, Loder, Elizabeth, Briggs, Andrew H., David Moher, Briggs, Andrew H, null null, Michael Drummond, Augustovski, F., Drummond, Michael   +33 more
core   +2 more sources

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Economic Evaluation of Pharmacy Services

, 2016
Economic Evaluation of Pharmacy Services provides the latest on the trend to a more product-centered and service-centered practice, eschewing traditional economic evaluation techniques that focus on product-to-product comparisons in favor of evaluating ...
Babar, Zaheer Ud Din, Babar, Zaheer, Babar, Zaheer-Ud-Din   +2 more
core   +1 more source

Burden of disease of Alzheimer disease in Italy: a real-world data analysis

BMC Health Services Research
Background Alzheimer Disease (AD) represents a growing global health concern with profound socioeconomic implications, with predictions indicating a potential 50% increase in AD cases in Italy over the next 30 years.
Francesco Saverio Mennini, Paolo Sciattella, Matteo Scortichini, Raffaele Migliorini, Marco Trabucco Aurilio, Andrea Marcellusi, Angelo Bianchetti   +6 more
doaj   +1 more source

Development and validation of a biological frailty score based on CRP, haemoglobin, albumin and vitamin D within an electronic health record database in France: a cross-sectional study

BMJ Public Health
Objectives To easily detect frailty in a timely fashion, enabling targeted interventions and appropriate monitoring, will be a major worldwide public health and economic challenge as the proportion of older people increases in the population.
Elodie Drumez, François Puisieux, Michael Genin, Pierre Balaye, Ivan Bautmans, Jean-Baptiste Beuscart, Aurélie Mailliez, Maxime Leroy, Eric Boulanger   +8 more
doaj   +1 more source