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Decrypting cancer's spatial code: from single cells to tissue niches

open access: yesMolecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik   +4 more
wiley   +1 more source

Does firm size affect client targeting? An investigation over the clients of the Indian Microfinance Institutions

open access: yesHumanities & Social Sciences Communications, 2023
The study examines the impact of the Microfinance Institutions’ (MFIs) size on their client targeting. Using MFI clients’ household data, the study considers household income, wealth, human development, caste, settlement type, and purposes of loans as ...
Sunil Sangwan   +3 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

The Localization of Pharmaceutical Clinical Research in Europe [PDF]

open access: yesHospital Practices and Research, 2017
Background: Clinical research is a specific phase of the production process in the pharmaceutical industry in which companies test candidate drugs on patients in order to collect clinical evidence about safety and effectiveness.Objective: This paper is ...
Greta Falavigna, Roberto Ippoliti
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Intention or Request: The Impact of Message Structures

open access: yesGames, 2021
This paper investigates how different message structures impact communication strategy as well as sender and receiver behavior. Specifically, we focus on comparing communication games with messages stating an intention versus a request.
Siyu Wang, Timothy Flannery
doaj   +1 more source

Card games are effective tools to enhance foundation year health and safety inductions

open access: yesFEBS Open Bio, EarlyView.
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq   +4 more
wiley   +1 more source

Poverty and Inequality Reduction in Brazil – A Parenthesis in History or the Road Ahead?

open access: yesIberoamericana: Nordic Journal of Latin American and Caribbean Studies, 2016
Between 1992 and 2013, and especially since 2003, Brazil experienced an unprecedented reduction in poverty and income inequality, a process common to several Latin American countries.
Luis Henrique Paiva
doaj   +1 more source

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