Results 41 to 50 of about 7,905,469 (263)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Cost-effectiveness analysis of active day patient treatment, an interdisciplinary pain self-management program

PAIN Reports
. Introduction:. Active day patient treatment (ADAPT) is an interdisciplinary, multimodal pain management program for patients with disabling chronic pain at the Pain Management & Research Centre (PMRC), Royal North Shore Hospital in Sydney, Australia ...
Anonnya Rizwana Chowdhury, Deborah Schofield, Rupendra Shrestha, Michael Nicholas   +3 more
doaj   +1 more source

Not business as usual: Engaging the corporate sector in India’s TB elimination efforts

Global Public Health, 2023
India has the highest global burden of tuberculosis (TB), accounting for a quarter of the worldwide TB disease incidence. Given the magnitude of India’s epidemic, TB has enormous economic implications.
Madeline Carwile, Chelsie Cintron, Komal Jain, Giancarlo Buonomo, Matt Oliver, Madolyn Dauphinais, Prakash Babu Narasimhan, Senbagavalli Prakash Babu, Sonali Sarkar, Lindsey Locks, Nalin Kulatilaka, Natasha Hochberg, Subitha Lakshminarayanan, Pranay Sinha   +13 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Cascade testing in mitochondrial diseases: a cross-sectional retrospective study

BMC Neurology
Background Cascade testing can offer improved surveillance and timely introduction of clinical management for the at-risk biological relatives. Data on cascade testing and costs in mitochondrial diseases are lacking.
Sameen Haque, Karen Crawley, Deborah Schofield, Rupendra Shrestha, Carolyn M. Sue   +4 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Impatti economici dell’interruzione del servizio irriguo consortile nell’area della Capitanata (Puglia). Stima empirica per il pomodoro da industria nel periodo 2001-2016

Aestimum, 2019
In this research an empirical evaluation of the economic impacts on tomato production due to the reduced water availability for irrigation is proposed.
Giacomo Giannoccaro, Arturo Casieri, Rossella de Vito, Donato Zingaro, Ivan Portoghese   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Social provisions in patients with mitochondrial diseases

BMJ Neurology Open
Background Mitochondrial diseases often follow a chronic, multimorbid disease course in adults. Like other chronic conditions, mitochondrial diseases present a challenge to public and community health models and patients are potentially at higher risk of
Deborah Schofield, Rupendra Shrestha, Carolyn M Sue, Ryan Davis, Sameen Haque, Karen Crawley   +5 more
doaj   +1 more source