Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Essential contributions of wildlife health surveillance to the United Nations Sustainable Development Goals. [PDF]
Noguera Z LP +10 more
europepmc +1 more source
Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen +5 more
wiley +1 more source
Geospatial modelling for zoonotic disease hotspot identification within a One Health framework: a systematic review. [PDF]
Nyengere J +11 more
europepmc +1 more source
AI‐Assisted Workflow for (Scanning) Transmission Electron Microscopy: From Data Analysis Automation to Materials Knowledge Unveiling. Abstract (Scanning) transmission electron microscopy ((S)TEM) has significantly advanced materials science but faces challenges in correlating precise atomic structure information with the functional properties of ...
Marc Botifoll +19 more
wiley +1 more source
Prevalence and risk factors of neglected zoonoses in Ethiopian small ruminants: a focus on Q fever, brucellosis, chlamydiosis, and toxoplasmosis. [PDF]
Alemayehu G +8 more
europepmc +1 more source
Engineered Protein‐Based Ionic Conductors for Sustainable Energy Storage Applications
Rational incorporation of charged residues into an engineered, self‐assembling protein scaffold yields solid‐state protein films with outstanding ionic conductivity. Salt‐doping further enhances conductivity, an effect amplified in the engineered variants. These properties enable the material integration into an efficient supercapacitor.
Juan David Cortés‐Ossa +14 more
wiley +1 more source
Environmental and socio-economic determinants of malaria transmission in West Africa: a systematic review. [PDF]
Gbaguidi GJ +4 more
europepmc +1 more source
Metal‐free carbon catalysts enable the sustainable synthesis of hydrogen peroxide via two‐electron oxygen reduction; however, active site complexity continues to hinder reliable interpretation. This review critiques correlation‐based approaches and highlights the importance of orthogonal experimental designs, standardized catalyst passports ...
Dayu Zhu +3 more
wiley +1 more source
From commitment to action: lessons from 18 transdisciplinary projects addressing health risks in wildlife trade. [PDF]
Li H +5 more
europepmc +1 more source

