Results 91 to 100 of about 31,106,490 (378)

The transformation of earth-system observations into information of socio-economic value in GEOSS [PDF]

, 2005
The Group on Earth Observations System of Systems, GEOSS, is a co-ordinated initiative by many nations to address the needs for earth-system information expressed by the 2002 World Summit on Sustainable Development.
Ad De Roo, Andersen, Andersson, Anthony Hollingsworth, Arduino, Buizza, Cantelaube, Challinor, Cho, Christian Pfrang, David Burridge, De Roo, Divakaria, Doblas-Reyes, Dobslaw, Ernst Klinker, Ferranti, Fetzer, Frederic Vitart, Gerritsen, Gouweleeuw, Hagedorn, Hollingsworth, Hollingsworth, J. W. De Vries, Jeanette Onvlee, Kosatsky, Marletto, McNally, Palmer, Pappenberger, Sakari Uppala, Simmons, Strow, Susskind, Syed, Tapley, Taylor, Thomson, Uppala, Vitart, Vitart   +41 more
core   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source

Economic incongruities in the European patent system [PDF]

Bruno van Pottelsberghe argues that the consequences of the fragmentation of the European patent system are more dramatic than the mere prohibitive costs of maintaining a patent in force in many jurisdictions.
Bruno van Pottelsberghe
core   +1 more source

SYHA1813, A VEGFR and CSF1R Inhibitor, in Patients With Recurrent High‐Grade Gliomas: A Multicenter, Open‐Label Phase I Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang, Shenglan Li, Liang Wang, Qianxue Chen, Weiguo Hu, Ting Lei, Ying Mao, Jing Zhang, Xiaojun Xiang, Qiming Wang, Zhengwen He, Tao Sun, Yulei Wang, Mengqian Huang, Rong Zhang, Feng Chen, Wenbin Li   +16 more
wiley   +1 more source

Information systems and economics

Communications of the ACM, 1998
Do big dollar expenditures on information systems pay off? Friction-free: is that what we really want markets to be? Is it time for consumers to say goodbye to fixed pricing? The Internet creates an environment in which the cost of buyer-seller interactions is cheaper than ever, and consumers can participate in the price-setting process—revealing ...
KAUFFMAN, Robert J., Riggins, Frederick J.   +1 more
openaire   +3 more sources

Lithuanian financial system transformation in the context of globalization [PDF]

, 2013
Purpose of the article: The purpose of the article is to discuss the transformation of the Lithuania finance system in the context of globalization. Exploring the interdependence between the financial system and the economy, in different periods. Analyze
Balkevicius, Arturas
core   +1 more source

Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Many patients with Multiple Sclerosis (MS) experience nonspecific symptoms prior to diagnosis. This period—the 'MS prodrome'—has been described in socio‐economically homogeneous cohorts to date. It remains unclear to what extent events prior to an MS diagnosis differ according to social determinants of health. Methods We conducted a
Pooja Tank, Benjamin M. Jacobs, Jonathan Bestwick, Ruth Dobson   +3 more
wiley   +1 more source

MINNESOTA ENERGY-ECONOMIC INFORMATION SYSTEM [PDF]

The energy-economic impact forecasting system presented here is a modular approach to both economic modeling and information systems development. A set of eleven modules--market, investment, demand, production, (input-output), employment, value added ...
Maki, Wilbur R., Turnquist, R.E., Venegas, Ernesto C.   +2 more
core   +1 more source

Modeling Commodity Flow as a Statistical Function of Lock Unavailability and Usage [PDF]

, 2018
The inland waterway system in the United States allows for the transportation of commodities, and interruptions to the system can have remarkable economic consequences.
McGee, Grace
core   +2 more sources

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source