Results 241 to 250 of about 1,685,614 (285)

Quorum Sensing Inhibits Type III‐A CRISPR‐Cas System Activity Through Repressing Positive Regulators SarA and ArcR in Staphylococcus Aureus

open access: yesAdvanced Science, EarlyView.
This study proposes a novel model illustrating how quorum sensing (QS) regulates the type III‐A CRISPR‐Cas system in Staphylococcus aureus. The QS regulator AgrA suppresses CRISPR‐Cas activity by downregulating the transcriptional regulators SarA and ArcR.
Yang Li   +6 more
wiley   +1 more source

Biohybrid Computing with Proteinoids and Algae

open access: yesAdvanced Science, EarlyView.
We developed a novel biohybrid computing system by combining proteinoid microspheres with algae. The biological mixture creates spontaneous electrical oscillations. These oscillations can perform simple logic operations, such as AND, OR, NAND, and NOR gates. Environmental factors like temperature and pH affect how the system works.
Panagiotis Mougkogiannis   +1 more
wiley   +1 more source

T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea)

open access: yesAdvanced Science, EarlyView.
This study presents telomere‐to‐telomere genome assemblies for two populations of Larimichthys crocea. We identified centromere‐specific tandem repeats invaded by LTR/ERV1 retrotransposons, unique 5S rRNA enrichment patterns, and population‐specific structural variants. Comparative genomic analyses further reveal distinct adaptive mechanisms in the MYD
Yu Cui   +9 more
wiley   +1 more source

Boosting the Charge Output of Enclosed Liquid‐Based Nanogenerators by Electrowetting‐Assisted Charge Injection Approach

open access: yesAdvanced Science, EarlyView.
The study introduces an electrowetting‐assisted charge injection (EWCI) approach to significantly enhance the charge density of enclosed liquid‐based nanogenerators (EW‐NGs). By leveraging EWCI, the volumetric output charge density reaches 19.1 mC m⁻3, a ninefold improvement over the conventional methods. Successfully powering a 10‐inch LCD screen, the
Ye Zhao   +8 more
wiley   +1 more source

Biodiversity conservation requires integration of species-centric and process-based strategies. [PDF]

open access: yesProc Natl Acad Sci U S A
Tobias JA   +4 more
europepmc   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

open access: yesAdvanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu   +8 more
wiley   +1 more source

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