Results 51 to 60 of about 76,225 (314)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Biodiversity and ecosystem services in the Frome catchment, Purbeck district, United Kingdom

, 2013
A map for valuing ecosystem services in the 480 km2 Frome catchment, to investigate scenarios of change in land use, was internet crowd-sourced. Scouts mapped deer habitats in 15% of the 30 km2 Arne Parish, while 143 residents volunteered data on deer ...
Newton, AC, Uzal, A, Hodder, KH, Kenward, RE   +3 more
core   +1 more source

Using citizen science data to inform the relative sensitivity of waterbirds to natural versus human‐dominated landscapes in China

Ecology and Evolution, 2020
Habitat loss is widely regarded as one of the most destructive factors threatening native biodiversity. Because migratory waterbirds include some of the most globally endangered species, information on their sensitivity to landscape would benefit their ...
Houlang Duan, Shaoxia Xia, Xiubo Yu, Yu Liu, Jiakun Teng, Yuehan Dou   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Satellite-Based Inversion and Field Validation of Autotrophic and Heterotrophic Respiration in an Alpine Meadow on the Tibetan Plateau

Remote Sensing, 2017
Alpine meadow ecosystem is among the highest soil carbon density and the most sensitive ecosystem to climate change. Partitioning autotrophic (Ra) and heterotrophic components (Rm) of ecosystem respiration (Re) is critical to evaluating climate change ...
Ben Niu, Yongtao He, Xianzhou Zhang, Ning Zong, Gang Fu, Peili Shi, Yangjian Zhang, Mingyuan Du, Jing Zhang   +8 more
doaj   +1 more source

Comparative Analysis on the Estimation of Diurnal Solar-Induced Chlorophyll Fluorescence Dynamics for a Subtropical Evergreen Coniferous Forest

Remote Sensing, 2021
Solar-induced chlorophyll fluorescence (SIF) is considered as a prospective indicator of vegetation photosynthetic activity and the ecosystem carbon cycle.
Jinghua Chen, Shaoqiang Wang, Bin Chen, Yue Li, Muhammad Amir, Li Ma, Kai Zhu, Fengting Yang, Xiaobo Wang, Yuanyuan Liu, Pengyuan Wang, Junbang Wang, Mei Huang, Zhaosheng Wang   +13 more
doaj   +1 more source

Modeling and Security in Cloud Ecosystems [PDF]

Future Internet, 2016
Clouds do not work in isolation but interact with other clouds and with a variety of systems either developed by the same provider or by external entities with the purpose to interact with them; forming then an ecosystem. A software ecosystem is a collection of software systems that have been developed to coexist and evolve together.
Eduardo B. Fernández, Nobukazu Yoshioka, Hironori Washizaki, Madiha H. Syed   +3 more
openaire   +2 more sources

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source