Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang +14 more
wiley +1 more source
Multiscale strategies to enhance plant resilience under climate change. [PDF]
Balsera M, Pérez-Ruiz JM, Serrato AJ.
europepmc +1 more source
Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke +32 more
wiley +1 more source
Biodiversity loss will decrease the future creditworthiness of nations. [PDF]
Agarwala M +5 more
europepmc +1 more source
Closing Knowledge Gaps on Global Budget of Nitrogen Oxides (NO<sub>x</sub>) by Quantifying Indirect Emissions From Anthropogenic Nitrogen. [PDF]
Wang Y +16 more
europepmc +1 more source
What is the cost of equity in assistive technology? A tool for calculating assistive products and services. [PDF]
Layton N +4 more
europepmc +1 more source
Modelling forest carbon stocks on the Canary Islands. [PDF]
Otto R +8 more
europepmc +1 more source
Darkness and body size shaped end-Cretaceous marine extinction patterns. [PDF]
Ying R +3 more
europepmc +1 more source
Returning an extirpated native carnivore to its former range: a habitat suitability analysis of Kangaroo Island for spotted-tailed quolls (Dasyurus maculatus). [PDF]
Retallack M +3 more
europepmc +1 more source

