Results 41 to 50 of about 7,359,513 (299)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Refining Fisheries Advice With Stock-Specific Ecosystem Information

Frontiers in Marine Science, 2021
Although frequently suggested as a goal for ecosystem-based fisheries management, incorporating ecosystem information into fisheries stock assessments has proven challenging.
Jacob W. Bentley, Jacob W. Bentley, Mathieu G. Lundy, Daniel Howell, Steven E. Beggs, Alida Bundy, Francisco de Castro, Clive J. Fox, Johanna J. Heymans, Johanna J. Heymans, Christopher P. Lynam, Debbi Pedreschi, Pia Schuchert, Natalia Serpetti, Natalia Serpetti, Johnny Woodlock, David G. Reid   +16 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Toward Robust Parameterizations in Ecosystem‐Level Photosynthesis Models

Journal of Advances in Modeling Earth Systems, 2023
In a model simulating dynamics of a system, parameters can represent system sensitivities and unresolved processes, therefore affecting model accuracy and uncertainty.
Shanning Bao, Lazaro Alonso, Siyuan Wang, Johannes Gensheimer, Ranit De, Nuno Carvalhais   +5 more
doaj   +1 more source

Unified Digital Business-Models of Platform and Ecosystem Participants

Вестник Российского экономического университета имени Г. В. Плеханова, 2022
Accumulated experience and advanced technologies provide an opportunity for the bank to develop new methods of competition and, therefore, to design new business-models. It is promoted by fast proliferation of digital platforms and ecosystems.
O. E. Kalenov
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Geographic isolation and climatic heterogeneity shape the genetic diversity of Blarinellini (Eulipotyphla: Soricidae) in the Hengduan Mountains [PDF]

Vertebrate Zoology
The Hengduan Mountains of southwestern China constitute a classic sky-island system shaped by complex topography and climatic history. We investigated the evolutionary history of the shrew tribe Blarinellini using 272 samples representing both genera and
Haixin Diao, Yuxin Xiong, Wenli Nie, Xiaoxin Pei, Wenyu Song, Xiaohan Wang, Kenneth Otieno Onditi, Hongjiao Wang, Quan Li, Xueyou Li, Kai He, Zhongzheng Chen, Xuelong Jiang   +12 more
doaj   +3 more sources

Modelling encounter rates and distribution of mobile predators and prey [PDF]

, 2009
Marine ecosystem models often contain modules for two phytoplankton compartments (flagellates and diatoms) and two zooplankton groups (micro- and mesozooplankton).
Fiksen, Øyvind, Huse, Geir
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source