Results 111 to 120 of about 26,407 (268)

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

ALANIS: a joint ESA–iLEAPS atmosphere–land interaction study over boreal Eurasia

, 2010
Determining the role of the Eurasian boreal region is essential in understanding the global Earth system as it represents the largest terrestrial ecosystem on the planet.
Marconcini, Mattia, Hayman, Garry, Helbert, Jérôme, Fernàndez–Prieto, Diego, Simon, Pinnock, de Leeuw, Gerrit   +5 more
core  

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

Impacts of groundwater storage variability on soil salinization in a semi-arid agricultural plain

Geoderma
Soil salinization, which is significantly influenced by groundwater storage dynamics, leads to reduced land productivity, loss of arable land, and degradation of vegetation, thereby posing a substantial threat to global food security and ecosystem ...
Geng Cui, Yan Liu, Xiaojie Li, Shan Wang, Xiangning Qu, Lei Wang, Shouzheng Tong, Mingye Zhang, Xiaofeng Li, Wenqiang Zhang   +9 more
doaj   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Comprehensive UAV and ground data for typical semiarid sites in the midstream of the Heihe River Basin

Scientific Data
Understanding land surface processes in arid and semiarid environments is crucial for ecosystem dynamics and water management. This data descriptor presents a comprehensive dataset collected during the MUlti-Scale Observation Experiment on land Surface ...
Ji Zhou, Ziwei Wang, Shaomin Liu, Mingsong Li, Jin Ma, Lingxuan Meng, Nanjie Feng   +6 more
doaj   +1 more source

Introduction to the sampling designs of the National Ecological Observatory Network Terrestrial Observation System

Ecosphere, 2016
Global change drivers influence ecological processes at multiple scales and manifest across most of Earth as changes in biodiversity, biogeochemical cycles, infectious disease incidence, and ecohydrology.
Andrea S. Thorpe, David T. Barnett, Sarah C. Elmendorf, Eve‐Lyn S. Hinckley, David Hoekman, Katherine D. Jones, Katherine E. LeVan, Courtney L. Meier, Lee F. Stanish, Katherine M. Thibault   +9 more
doaj   +1 more source