ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Redefining the Health Risk of Battery Materials Through a Biologically Transformed Metal Mixture
Advanced Science, EarlyView.Inhaled NCM particles undergo lysosomal degradation, releasing complex ion mixtures that induce systemic impact. The impact is determined by a critical balance between antagonistic Ni‐Co interactions and synergistic Mn effects. To capture these complexities in risk assessment, we develop an IAI model, ensuring a more accurate quantitative risk ...
Ze Zhang +11 more
wiley +1 more source
Implications of differences between temperate and tropical freshwater ecosystems for the ecological risk assessment of pesticides [PDF]
Despite considerable increased pesticide use over the past decades, little research has been done into their fate and effects in surface waters in tropical regions.
Brink, P.J., van den, Daam, M.A.
core +2 more sources
High bioaccumulation of cadmium and other metals in Patagonian edible gastropods [PDF]
, 2017 High concentrations of metals are accumulated by edible marine resources, affecting human health. Marine gastropods have been commercially captured and consumed in Argentina for decades without official regulations or studies to guarantee their safety ...
Bigatti, Gregorio +2 more
core +1 more source
Environmental Toxicology and Chemistry, EarlyView.Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal +7 more
wiley +1 more source
Gut Microbiota Manipulation to Mitigate the Detrimental Effects of Environmental Pollutants
Toxics, 2021 The ecotoxicology and human health risks of environmental pollutants are creating global concern, especially in the context of the prevalent and severe contamination of environmental abiotic and biotic compartments [...]
Lianguo Chen
doaj +1 more source
The use of simulated whole effluents in toxicity assessments: A review of case studies from reverse osmosis desalination plants [PDF]
, 2014 Seawater desalination is an increasingly common means to meet the demand for freshwater. Resulting wastewater discharges can, however, impact biota of the surrounding environment.
Falkenberg, LJ, Styan, CA
core
Using a new high-throughput video-tracking platform to assess behavioural changes in Daphnia magna exposed to neuro-active drugs [PDF]
, 2019 © 2019. ElsevierOne of the major challenges that faces today regulatory risk assessment is to speed up the way of assessing threshold sublethal detrimental effects of existing and new chemical products.
Barata Martí, Carlos +8 more
core +1 more source
Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines
Environmental Toxicology and Chemistry, EarlyView.Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz +4 more
wiley +1 more source
Journal of Nanotechnology, 2019 Background. The effect of nanoparticles (NPs) on aquatic environments is poorly studied. Aim. This study evaluates the toxicity of joint effects of these different metal nanoparticles and their bulk in mixtures (Al2O3, CuO, and SiO2) on fish using ...
Amaeze Henry Nnamdi +3 more
doaj +1 more source