Results 221 to 230 of about 26,254 (308)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Integrative single-cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers. [PDF]

Clin Transl Med
Huang L, Hou H, Zhang X, Dong L, Shi W, Liu M, Sun J, Prakash A, Song H, Pei S, Li X, Chen X, Mei S, Yin M.   +13 more
europepmc   +1 more source

Plant‐Derived Melatonin Inhibits Bacterial Virulence via CpxA/R Two‐Component System

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Plant‐derived melatonin is sensed by CpxAE48/T51, which inhibits the phosphorylation cascade transmission from CpxAH240 to CpxRD52, resulting in the inhibition of DNA‐binding capacity of CpxR and subsequent T3SS genes expression in Pst DC3000. ABSTRACT In defending against pathogens, plants deploy diverse secondary metabolites and signaling molecules ...
Jin‐Wei Wei, Wei Liu, Bili Cao, Dan Zhao, Chengqiang Wang, Xin Hou, Tangyuan Ning, Biao Gong   +7 more
wiley   +1 more source

Fibroblast TGF-β signaling defines spatial tumor ecosystems linked to immune checkpoint blockade resistance. [PDF]

Commun Biol
Lee SY, Lee Y.
europepmc   +1 more source

Genomic Variation and Population Structure of Portuguese Native Dog Breeds

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The presence of dogs in Portugal is confirmed by zooarchaeological evidence dating to at least 7600 years ago. The 11 native dog breeds that exist in this territory are therefore the end‐product of a complex evolutionary process. This study characterises the genomic diversity and population structure of 10 native breeds based on whole‐genome ...
Ludmilla Blaschikoff, Octávio Serra, Fernanda Simões, Catarina Ginja, Ana Elisabete Pires   +4 more
wiley   +1 more source

From microbial diversity to functional potential using dimensionality reduction. [PDF]

Front Microbiol
Chamberlain EJ, Boulton W, Connors E, Calianos T, Bowman JS, Creamean JM, Mock T, Kim HH.   +7 more
europepmc   +1 more source

Pollination by long‐proboscid horseflies and its implications for reproductive isolation among coflowering Satyrium orchids in South Africa

American Journal of Botany, Volume 113, Issue 6, June 2026.
Abstract Premise Floral adaptations to pollinators can drive lineage diversification and promote coexistence of species. We investigated the reproductive biology of Satyrium longicolle, a South African orchid that we hypothesized to belong to a long‐proboscid horsefly pollination guild and examined overlap of pollinators and floral traits among ...
Steven D. Johnson, Matthew Moir, Ethan Newman, Timotheüs Van der Niet   +3 more
wiley   +1 more source

Ecotypic divergence in Mongolian Scots pine persists via large-effect genetic adaptation and phenotypic plasticity. [PDF]

BMC Plant Biol
Wuyuntana, Fong Q, Ke CY, Gao DM, Luo MX, Yang YZ, Gao RH, Liao PC.   +7 more
europepmc   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, Volume 101, Issue 3, Page 1491-1510, June 2026.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

Biological Activities and Phenolic Profile of <i>Bursera microphylla</i> A. Gray: Study of the Magdalena Ecotype. [PDF]

Plants (Basel)
Torres-Moreno H, López-Romero JC, Vidal-Gutiérrez M, Rodríguez-Martínez KL, Robles Zepeda RE, Vilegas W, Oros-Morales A.   +6 more
europepmc   +1 more source