Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota +14 more
wiley +1 more source
Benzodiazepines and Effectiveness of ECT [PDF]
Johnstone, E C +6 more
openaire +4 more sources
Joint Risk Factor Combinations with Additive Interaction Increase the Risk of Parkinson's Disease
Abstract Background Combined effects of multiple risk factors on incident late‐onset Parkinson's disease (PD; LOPD) remain poorly characterized. Objective The objective of this study was to quantify the impact of joint risk exposures and estimate the contribution of potentially modifiable factors to incident LOPD risk.
Andrea Quattrone +5 more
wiley +1 more source
Safety and Feasibility of Endoscopic-Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer: An Exploratory Randomised Clinical Trial. [PDF]
Ngo-Stuyt L +11 more
europepmc +1 more source
Apathy in Lewy Body Disorders: A Position Paper
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky +12 more
wiley +1 more source
Joan Abaatyo,1,2 Mark Mohan Kaggwa3,4 1Department of Psychiatry, Uganda Christian University, Kampala, Uganda; 2King Ceasor University, Kampala, Uganda; 3Department of Psychiatry and Behavioural Neurosciences, McMaster University, Ontario, ON, Canada ...
Abaatyo J, Kaggwa MM
doaj
Characteristics and outcomes of early-terminated acute electroconvulsive therapy courses: A retrospective cohort study. [PDF]
Oflezer C, Atay O.
europepmc +1 more source
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
Electrochemotherapy for cutaneous tumors combined with tumor irradiation before or after treatment: feasibility, safety, and effectiveness. [PDF]
Bertino G +10 more
europepmc +1 more source

