Results 241 to 250 of about 527,852 (334)

ECT anaesthetics [PDF]

open access: yesBritish Journal of Psychiatry, 1992
openaire   +2 more sources

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

open access: yesEpilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

ECT CAN SAVES LIVES

open access: bronze, 1984
Rachel Rust Carl
openalex   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

open access: yesEpilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson   +9 more
wiley   +1 more source

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

open access: yesEpilepsia, EarlyView.
Abstract SCN2A encodes for the alpha subunit of the voltage‐gated sodium channel NaV1.2, which is involved in action potential initiation and backpropagation in excitatory neurons. Currently, it is one of the highest monogenetic risk factors for both epilepsy and autism spectrum disorder.
Katelin E. J. Scott   +2 more
wiley   +1 more source

Nanoparticle‐encapsulated neuropeptide Y provides robust seizure protection in SCN1A‐derived epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Neuropeptides have garnered great interest as potential treatments for epilepsy due to their impact on neuronal excitability through modulation of ion channels and neurotransmitter receptor activity. Neuropeptide Y (NPY) is a 36‐amino acid neuropeptide that is expressed primarily by γ‐aminobutyric acidergic (GABAergic) interneurons ...
Samantha L. Reed   +8 more
wiley   +1 more source

Restoring Balance: The Intersection of Management and Fishing Sustainability in Indonesia

open access: yesFisheries Management and Ecology, EarlyView.
ABSTRACT As the world's second‐largest fish producer, Indonesia plays a crucial role in global fishing. However, overfishing, habitat degradation, population growth, and container port traffic threaten the sustainability of the fishing industry. We examined the impacts of fishing, population growth, and container port traffic on Indonesia's fishing ...
Kirca Mustafa   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy