Results 31 to 40 of about 2,813 (161)

Surgical management of non-syndromic ectopia lentis [PDF]

International Journal of Ophthalmology, 2020
AIM: To compare whether aphakic contact lenses or secondary iris-claw intraocular lenses are superior in the refractive management post-pars plana vitreolensectomy in a pedigree with an FBN1 mutation causing non-syndromic ectopia lentis (NSEL) with ...
Kirk AJ Stephenson, Michael O'Keefe, David J Keegan   +2 more
doaj   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

A CASE OF LATE DIAGNOSIS OF MARFAN SYNDROME

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2019
Background. Marfan syndrome (MS) is a hereditary connective tissue disease (HCTD), which is accompanied by the development of aortic aneurism, ectopia lentis and signs of systemic involvement of connective tissue with high risk of fatal outcome in young ...
Shelkovich Yu. Ya., Shyshko V. I., Snitko V. N., Kavalenia P. A., Larionova I. N., Gorbacheva S. V.   +5 more
doaj   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Weill–Marchesani syndrome: A rare cause of ectopia lentis and short stature

Indian Pediatrics Case Reports, 2021
Background: Weill–Marchesani syndrome (WMS) is a rare heritable connective disorder characterized by short stature, brachydactyly, stiff joints and distinctive ocular manifestations of microspherophakia, myopia, ectopia lentis, and glaucoma. It is caused
Sapna Sandal, Varshini Shanker, Swasti Pal, Sunita Bijarnia-Mahay   +3 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Ectopia lentis in Marfan syndrome

PAMJ Clinical Medicine, 2020
We report the case of a 6-year-old-child, with history of mitral valve disease, he was diagnosed suffering from Marfan syndrome. He was brought to ophtalmological consultation for decreased visual acuity.
Narjisse Taouri, Nourdine Boutimzine
doaj   +1 more source

Síndrome de marfán con malformación ósea tipo pectus carinatum: reporte de un caso en Cartagena de indias. Colombia

Revista Ciencias Biomédicas, 2020
El síndrome de Marfán (MFS) es la enfermedad del tejido conectivo más común de origen  genético, con transmisión hereditaria autosómica dominante. La mutación se localiza en el gen  FBN1 que codifica para la proteína Fibrilina-1.
Dacia I. Malambo García, Gustavo J. Mora García, José C. Pomares Estrada, Cristian Gómez García (q.e.p.d.), Doris E. Gómez Camargo   +4 more
doaj   +1 more source

Endoscopy-guided in vivo evaluation of ciliary sulcus location in children with ectopia lentis

Journal of International Medical Research, 2021
Objective To assess a new method to measure the distance of the needle passage from the ciliary sulcus to the corneal limbus anterior border (CTC) in eyes with ectopia lentis directly in vivo via endoscopy and to further evaluate the correlations among ...
Jing Yang, Zhirong Wang, Qianzhong Cao, Yiyao Wang, Jieyi Wu, Zhangkai Lian, Danying Zheng   +6 more
doaj   +1 more source