Results 71 to 80 of about 3,283 (186)

Implante de lente intraocular de fixação iriana em crianças com ectopia lentis

, 2016
Purpose: Artisan iris-claw lens implantation (AICLI) is a surgical technique for treating ectopia lentis. We aimed to compare visual outcomes and possible long-term complications of AICLI surgery in pediatric patients with ectopia lentis with or without ...
Çevik, Görkem Sadık, Çevik, Muhammer Özgür   +1 more
core   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, Volume 12, Issue 48, December 29, 2025.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Ectopia lentis et pupillae in four generations caused by novel mutations in the ADAMTSL4 gene

, 2013
Item does not contain fulltextOBJECTIVES: To identify the phenotype, genetic defect and inheritance pattern of ectopia lentis et pupillae (ELP) in a large Dutch family, previously diagnosed as presumed autosomal dominant ELP because of the occurrence of ...
Cruysberg, JRM, Tjon-Fo-Sang, M.J. (Martha), Maat-Kievit, Anneke J., Maat-Kievit, A.A. (Anneke), Maat-Kievit, JA, Sharifi, Y., Cruysberg, J.R.M., Tjon-Fo-Sang, MJ, Cruysberg, Johannes R. M., Maat-Kievit, A.J., Cruysberg, J.R.M. (Johan), Sharifi, Yassi, Tjon-Fo-Sang, M.J., Sharifi, Y, Sharifi, Y. (Yassi), Tjon-Fo-Sang, Martha J.   +15 more
core   +1 more source

Combined Bentall and modified Ravitch procedures in a patient with Marfan syndrome

Journal of Anaesthesiology Clinical Pharmacology, 2013
Marfan syndrome is an inherited, connective-tissue disorder transmitted as an autosomal dominant trait. Cardinal features of the disorder include tall stature, ectopia lentis, mitral valve prolapse, aortic root dilatation, and aortic dissection.
Bhuvnesh Kansara, Ajmer Singh, Samir Girotra, K S Iyer   +3 more
doaj   +1 more source

A 2-Year-Old Child with Bilateral Ectopis Lentis and a Novel FBN1 Gene Variant Cys129Ser

, 2017
Marfan syndrome and dominant ectopia lentis are part of type 1 fibrillinopathies that are caused by FBN1 pathogenic variants. Making a diagnosis could be challenging due to the clinical overlap between these disorders. The revised Ghent criteria used for
Paldeep Atwal, Ahmed Mohammad
core   +1 more source

Microspherophakic Angle Closure Glaucoma in a Patient with Coffin-Siris Syndrome: Case Report

The Application of Clinical Genetics, 2023
Kulawan Rojananuangnit,1,* Kitiwan Rojnueangnit2,* 1Glaucoma Unit, Department of Ophthalmology, Mettapracharak (Wat Rai Khing) Hospital, Nakhon Pathom, Thailand; 2Division of Genetics, Department of Pediatrics, Faculty of Medicine, Thammasat ...
Rojananuangnit K, Rojnueangnit K
doaj  

Longitudinal Changes of Axial Length and Associated Factors in Congenital Ectopia Lentis Patients

, 2022
PURPOSE: To investigate the longitudinal changes and associated factors of axial length (AL) in congenital ectopia lentis (CEL) patients. METHODS: In this retrospective study, medical records of CEL patients were reviewed from January 2014 to December ...
Cao, Qianzhong, Qianzhong Cao, Danying Zheng, Lian, Zhangkai, Zhenzhen Liu, Zhangkai Lian, Zheng, Danying, Xinyu Zhang, Zhang, Xinyu, Liu, Zhenzhen, Charlotte Aimee Young, Guangming Jin, Jingxin He, He, Jingxin, Young, Charlotte Aimee, Jin, Guangming   +15 more
core   +1 more source

Management strategies of ocular abnormalities in patients with marfan syndrome: Current perspective

Journal of Ophthalmic & Vision Research, 2019
Marfan syndrome is an autosomal dominant genetic connective tissue disorder that results from mutations in the fibrillin-1 gene located on chromosome band 15q15–21. Fibrillin, a glycoprotein, is widely expressed throughout the body and contributes to the
Hamed Esfandiari, Shabnam Ansari, Hossein Mohammad-Rabei, Marilyn B Mets   +3 more
doaj   +1 more source

Characteristics of Anterior Segment in Congenital Ectopia Lentis: An SS-OCT Study

, 2022
PURPOSE: To investigate the characteristics of anterior chamber angle parameters in congenital ectopia lentis (CEL) patients and to evaluate the sensitivity and specificity of anterior segment parameters in distinguishing CEL from healthy controls ...
Haotian Qi, Liyan Liu, Young, Charlotte, Danying Zheng, Lian, Zhangkai, Zou, Minjie, Zhenzhen Liu, Liu, Liyan, Zhangkai Lian, Zheng, Danying, Qi, Haotian, Liu, Zhenzhen, Charlotte Young, Guangming Jin, Dongwei Guo, Guo, Dongwei, Jin, Guangming, Minjie Zou   +17 more
core   +1 more source

CASES OF HEREDITARY ECTOPIA LENTIS. [PDF]

JAMA: The Journal of the American Medical Association, 1898
The following interesting cases came under my observation in October, 1894, at the Illinois Eye and Ear Infirmary. Mrs. John H., brought her daughter Maggie, aged 10 years, to the clinic because of poor eyesight, saying the child could not see well at school. R.V.= 5/200, L.V.=10/200, only slightly improved with a strong convex glass, + 12 D.
openaire   +1 more source