Results 61 to 70 of about 504,608 (339)

Generation and escape of local waves from the boundary of uncoupled cardiac tissue [PDF]

, 2007
We aim to understand the formation of abnormal waves of activity from myocardial regions with diminished cell-to-cell coupling. In route to this goal, we studied the behavior of a heterogeneous myocyte network in which a sharp coupling gradient was ...
Agladze, Ara Arutunyan, Arutunyan, Arutunyan, Arutunyan, Beeler, Bers, Bogdanov, Bub, Carmeliet, Dhamoon, Dhein, Elizari, Entcheva, Entcheva, Entcheva, Iravanian, Karmazyn, Keener, Kies, Kleber, Lakkireddy, Lameris, Laurita, Masuda, Mills, Narine A. Sarvazyan, Pertsov, Peters, Peters, Pumir, Pumir, Rubart, Schlotthauer, Shen, Silva, Stevenson, Ter Keurs, Vadim N. Biktashev, Wahler, Warner, White, Yamada, Zipes   +43 more
core   +3 more sources

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Aberrant cervical thymus and the role of ultrasonography: A case report

The Turkish Journal of Pediatrics, 2016
Ectopic/aberrant cervical thymic tissue is a rare cause of neck mass and usually detected incidentally. Aberrant thymic tissue can occur anywhere in the course of thymic descent from the angle of the mandible to the superior mediastinum. We report
Emre Ünal, Hanife Gülden Düzkalır, Seray Kurt-Güney, Emek Tolga Işıldak   +3 more
doaj   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Genetic and Molecular Factors in Drug-Induced Liver Injury: A Review [PDF]

, 2007
The diagnosis of drug-induced liver injury (DILI) is challenging and based on complex diagnostic criteria. DILI falls into two main categories i) intrinsic 'dose-dependent' Type A reactions ii) 'idiosyncratic' or Type B reactions (which are usually not ...
Andrade, RJ, Carvajal, A, Cueto, R, Isabel Lucena, M, Molokhia, M, Pachkoria, K, Serrano Carballo, A   +6 more
core   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Ectopic Hidradenoma Papilliferum of Axilla: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
A benign adnexal tumour is a non cancerous growth located in the uterine tubes, ovaries, or near the uterus, including the surrounding connective tissue. While adnexal tumours can also be cancerous, they are predominantly benign. Moreover, adnexal masses
Purbasha Misra, Samarth Shukla, Rajesh Godavarthi   +2 more
doaj   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

Temporal response of ectopic activity in guinea pig ventricular myocardium in response to isoproterenol and acetylcholine

Frontiers in Physiology, 2015
Both beta adrenergic and muscarinic receptor stimulation independently potentiate arrhythmogenesis. However, the effect of simultaneous stimulation on arrhythmogenesis is not well known.
Amara eGreer-Short, Steven ePoelzing
doaj   +1 more source