Results 31 to 40 of about 319 (254)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2003 This paper traces the development in terms of its heritage and legacy of a Reformed Presbyterian Church in Southern Africa, from its beginnings in the Scottish Mission, to the present. It notes the oppressive role of missionary dominated Mission Councils
Graham A. Duncan
doaj +1 more source
Suleiman of Gazza on the Ecumenical Councils
Issues of Theology, 2023 The article discusses the ideas about the history and deeds of the Ecumenical Councils of the Melkite writer of the 10th–11th centuries Suleiman, Bishop of Gaza, the first Arabic-speaking Christian poet and author of a number of theological and philosophical treatises.
openaire +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2015 The Apostolic tradition in the Church’s understanding of Scripture and faith from Reformation to the start of the 21st century – A brief hermeneutical overview.
J.P. (Kobus) Labuschagne
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
The Role of Ecumenical Councils in Orthodox Church Management
Волинський благовісник, 2016 This article contains a review on the importance and significance of the Ecumenical Councils as a management system in existence of the Church, and reveals the essence of the Councils , it’s criteria and credentials.
Volodymyr Maliarchuk +1 more
doaj
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2015 The Apostolic tradition in the Early Church’s understanding of Scripture and faith – A brief hermeneutical overview. This study is a concise hermeneutical overview of faith’s various ways of understanding and of the different approaches towards Scripture
J.P. (Kobus) Labuschagne
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source