Results 31 to 40 of about 512 (217)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Ecumenism as Hope: The Prophetic Role and the Eschatological Function of the Church
Religions, 2023 The article is structured around one of the questions that has been at the forefront of controversies in the orthodox church in recent years: why is ecumenical dialogue necessary and why “must” we engage in it? The answer can be simple: because it is the
Cristian-Sebastian Sonea
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang +10 more
wiley +1 more source
Último Andar, 2016 O presente trabalho visa destacar a importância da cooperação ecumênica na afirmação e promoção de direitos. A delimitação utilizada é entre 1994 e 2013, na América Latina.
Darli Alves de Souza
doaj
HTS Teologiese Studies/Theological Studies, 2011 Since the Ottawa Consultation in 1982, the relationship between the Nederduitsch Hervormde Kerk van Afrika (NHKA) and the World Alliance of Reformed Churches (WARC) was nonexistent. In the NHKA it became progressively clear that it would be impossible to
Wim A. Dreyer
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Astra Salvensis, 2019 It is common and well-known fact that Holy See always identified itself as one the holy, catholic and apostolic Church. Roman Pontiffs were against ecumenical ideas and strongly condemned the movement which was organized in the beginning of XX-th century
Denis MELKOV
doaj
Tacit dewesternisation in the ecumenical movement: The example of the World Council of Churches
HTS Teologiese Studies/Theological StudiesDewesternisation is a concept still undergoing conceptual clarification and refinement. It is used in different theoretical approaches, often differently meant and assessed.
Piotr Kopiec
doaj +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source