Results 41 to 50 of about 163,045 (300)
Chemistry &Biodiversity, EarlyView.ABSTRACT The chemical composition of 66 oil samples isolated from the berries of individual trees of Juniperus phoenicea var. turbinata, collected in six locations from Algeria, was investigated by gas chromatography with flame ionization detection, gas chromatography‐mass spectrometry, and 13C‐nuclear magnetic resonance.
Chérifa Yassamine Osmani +6 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.(1R)‐ and (1S)‐Epimers of novel isoquinoline‐derived SPMs were prepared, with a Pd‐catalyzed Heck reaction and a Ru(II)‐catalyzed asymmetric transfer hydrogenation as the key synthetic steps. Biological assessment demonstrated that several analogues significantly attenuate lipopolysaccharide‐induced NF‐κB activation and downstream pro‐inflammatory ...
Denise Moran +4 more
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Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, EarlyView.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
, 2004 The remarkable rate of development of medical knowledge and pharmacology affects all medical specialties and in particular general practice, since the latter embraces various aspects of different medical fields. Certain areas of medical practice, such as
Abela, Jurgen C.
core
Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases [PDF]
, 2004 Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of ...
Atsuta J +33 more
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Clinical Pharmacology in Drug Development, EarlyView.Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano +8 more
wiley +1 more source
Atopic Dermatitis Anti-IgE Paediatric Trial (ADAPT): the role of anti-IgE in severe paediatric eczema: study protocol for a randomised controlled trial. [PDF]
, 2017 The evidence for systemic treatments for severe childhood eczema is limited and largely based on extrapolation of data from adult studies. Current therapies are often immunosuppressant and may be associated with both short- and long-term side effects ...
Chen, Tao
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Archives of Dermatology, 1920 THREE THEORIES CONCERNING ETIOLOGY OF ECZEMA The history of the early views held concerning the etiology of eczema has been well given by both Brocq1and Besnier.2These views, as well as those of more recent times, are admirably summarized in an excellent article by Highman.3The opinions of various men and of various schools are widely diverse and are ...
openaire +2 more sources
Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model
Barrier Immunity, EarlyView.ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia +4 more
wiley +1 more source