Results 51 to 60 of about 157,660 (290)

Characterizing local and systemic exposure to clobetasol propionate in healthy subjects and patients with atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims There is a potential risk of systemic side‐effects with the use of potent corticosteroids, such as clobetasol propionate (CP). This concern is of particular interest in paediatric patients. The aim of this study was to develop and verify a physiologically based pharmacokinetic (PBPK) model to describe the local and systemic exposure to CP
Janna K. Duong, Sven van Dijkman, Gary Ong, Alexandra Marta, Adriana Ceci, Ernesto Bonifazi, Oscar Della Pasqua   +6 more
wiley   +1 more source

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source

Visualisation of tissue kallikrein, kininogen and kinin receptors in human skin following trauma and in dermal diseases [PDF]

, 2004
During dermal injury and inflammation the serine proteases kallikreins cleave endogenous, multifunctional substrates (kininogens) to form bradykinin and kallidin.
Bhoola, Kanti D., Naidoo, Strinivasen, Neuhof, Christiane, Neuhof, Heinz, Sander, Christian, Schremmer-Danninger, Elisabeth, Snyman, Celia, Valeske, Klaus   +7 more
core   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Features of clinic and tool diagnostics of infectious (microbic) eczema

Vestnik Dermatologii i Venerologii, 2017
One of frequent forms of eczema is infectious (microbic) eczema, in recent years tending to heavier current. In certain cases differentiation between the endogenous eczema complicated by a piodermiya, and infectious eczema is difficult. The method of the
O. V. Lysenko, O. R. Ziganshin, L. V. Lukyanchikova   +2 more
doaj   +1 more source

Pollen grains induce a rapid and biphasic eczematous immune response in atopic eczema patients [PDF]

, 2008
Introduction: Eczematous reactions to type I allergy-inducing antigens are documented in a subgroup of patients with atopic eczema. Yet, the underlying immunological mechanisms are not well understood.
Behrendt, Heidrun, Darsow, Ulf, Eyerich, Kilian, Foerster, Stefanie, Huss-Marp, Johannes, Ring, Johannes, Traidl-Hoffmann, Claudia, Wollenberg, Andreas   +7 more
core   +2 more sources

Composition, Chemical Variability, and Anti‐inflammatory Activity of the Berry Essential Oil of Juniperus phoenicea L. var. Turbinata From Algeria

Chemistry &Biodiversity, EarlyView.
ABSTRACT The chemical composition of 66 oil samples isolated from the berries of individual trees of Juniperus phoenicea var. turbinata, collected in six locations from Algeria, was investigated by gas chromatography with flame ionization detection, gas chromatography‐mass spectrometry, and 13C‐nuclear magnetic resonance.
Chérifa Yassamine Osmani, Chahrazed Bekhechi, Charaf Eddine Watheq Malti, Haciba Meziane, Joseph Casanova, Mathieu Paoli, Félix Tomi   +6 more
wiley   +1 more source

Pharmacokinetics, Bioequivalence, and Safety Studies of Crisaborole Ointment in Healthy Chinese Subjects

Clinical Pharmacology in Drug Development, EarlyView.
Abstract The aim of this study was to evaluate the bioequivalence and safety of a single application of crisaborole ointment to test formulation and reference formulation in healthy subjects under fasting conditions. A total of 32 subjects were included and divided into 2 groups (test‐reference; reference‐test).
Yanchao Wang, Xiaofei Zhao, Taixin Wang, Luning Xiong, Xiujuan Liu, Jing Pan, Wen Yin, Chao Zhang, Jining Dong, Kexin Zhao   +9 more
wiley   +1 more source

Patient and caregiver motivators and barriers to eczema clinical trial participation: Analysis of survey data

Skin Health and Disease
Background Eczema clinical trials (CTs) are increasing in number, yet participation across the eczema community is low. Little is known about patient characteristics and views on motivators and barriers to CT participation (CTP).
Michael Evan Jacobson, Isabelle J. Thibau, Wenelia Baghoomian, Emile Latour, Ajai Kastala, Allison R. Loiselle, Eric Lawrence Simpson, Wendy Smith Begolka   +7 more
doaj   +1 more source

TREatment of ATopic eczema (TREAT) Registry Taskforce: consensus on how and when to measure the core dataset for atopic eczema treatment research registries. [PDF]

, 2019
BackgroundComparative, real-life and long-term evidence on the effectiveness and safety of phototherapy and systemic therapy in moderate-to-severe atopic eczema (AE) is limited.
Apfelbacher, CJ, Arents, BWM, Barbarot, S, Bosma, AL, Deleuran, M, Eichenfield, LF, Flohr, C, Gerbens, LAA, International TREAT Registry Taskforce, Irvine, AD, Manca, A, Middelkamp-Hup, MA, Schmitt, J, Spuls, PI, Vermeulen, FM, Vestergaard, C, Wall, D, Weidinger, S   +17 more
core