Results 211 to 220 of about 1,170,924 (343)

Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial Infarction

open access: yesCirculation, 2016
O. Henri   +14 more
semanticscholar   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

open access: yesAdvanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna   +11 more
wiley   +1 more source

Tocilizumab as a treatment tool for ROSAH syndrome: a case report. [PDF]

open access: yesJ Ophthalmic Inflamm Infect
Teixeira-Martins R   +6 more
europepmc   +1 more source

Affinity‐Based Protein Profiling Revealed that HIGD1A is a Direct Target Protein of Aristolochic Acids

open access: yesAdvanced Science, EarlyView.
Using an affinity‐based probe, this study reveals that aristolochic acid directly binds to HIGD1A with high affinity in the kidney. This binding disrupts the HIGD1A‐TFAM interaction, which in turn triggers TFAM degradation, cytosolic mitochondrial DNA release, and the activation of inflammatory pathways. Abstract Exposure to aristolochic acids (AA) via
Yin Gong   +15 more
wiley   +1 more source

Hyperadrenocorticism of calorie restriction contributes to its anti‐inflammatory action in mice [PDF]

open access: yes, 2019
Allen, Brian D   +6 more
core   +2 more sources

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

open access: yesAdvanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei   +8 more
wiley   +1 more source

Magnetically‐Induced Suppression of Oxidative Stress Prevents Venous Thrombosis

open access: yesAdvanced Science, EarlyView.
Venous thromboembolism (VTE) remains a leading cause of cardiovascular mortality. This study demonstrates that static magnetic fields (SMF) offer a novel non‐pharmacological intervention against VTE by mitigating endothelial oxidative stress. Mechanistically, SMF elevates intracellular Ca2+, boosts ATP production, and suppresses NOX4‐mediated ROS ...
Nana Zhang   +12 more
wiley   +1 more source

Editorial: Mechanisms, Measurement, and Management of Vasogenic Edema After Stroke

open access: yesFrontiers in Neurology, 2022
Gabriel Broocks   +3 more
doaj   +1 more source

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